Integrated Biostatistical Training for CVD Research

描述（由申请人提供）：本申请建议更新一个新的，综合的生物统计学博士前培训计划，重点是为心血管疾病研究的职业生涯做好准备。在这个激动人心的心血管疾病研究时代，有能力应对持续和新出现的挑战的熟练生物统计学家严重短缺，这要求进行培训，正式整合在多学科环境中合作的深入和持续经验，掌握有效应用复杂生物统计技术和研究开发新方法所需的统计学理论基础，强调沟通和领导能力。该计划将是北卡罗来纳州州立大学（NCSU）和杜克临床研究所（DCRI）统计系的共同努力，利用世界上最大的统计学研究生课程之一与研究机构之间的现有合作关系，该研究机构是同类中最大的，是心血管疾病研究前沿国际知名研究人员的所在地。五年计划将支持五（5）学员插槽在每年，将涉及统计理论的NCSU严格的研究，包括概率，推理，线性和其他统计模型，测量理论和先进的概率，先进的统计推断，和统计方法，包括临床试验设计/分析，纵向数据分析，生存分析，和前沿专题;生物学和心血管医学基础方面的培训;研究责任和道德方面的课程工作;以及沟通和领导技能方面的广泛正式和经验培训。学员将逐步被介绍到DCRI心血管疾病研究，发展到一个完整的协作学徒，他们被整合为DCRI项目团队的功能成员。通过这两个学徒和正式的课程和研讨会，学员将开发广泛的工作知识和心血管医学的专业知识，这将使他们能够立即作出贡献，心血管疾病的研究完成后，该计划。将为受训者分配一个机构间导师团队，该团队由每个研究中心的主要和次要生物统计学家导师以及DCRI的次要临床医生导师组成，他们将合作指导他们完成所有方面。论文研究将涉及新的统计方法的开发和评估，这些方法受到学员心血管疾病研究合作中遇到的挑战的启发。

DESCRIPTION (provided by applicant): This application proposes renewal of a novel, integrated program for predoctoral training in biostatistics focused on preparing trainees for careers in cardiovascular disease research. The critical shortage of skilled biostatisticians equipped to address ongoing and emerging challenges in this exciting era of cardiovascular disease research calls for training that formally integrates deep and sustained experience in collaboration in a multidisciplinary environment, mastery of the theoretical underpinnings of statistics required for valid application of sophisticated biostatistical techniques and for research on development of new methodology, and strong emphasis on communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NCSU) and the Duke Clinical Research Institute (DCRI), capitalizing on an existing partnership between one of the largest graduate programs in statistics in the world and a research institution that is the largest of its kind and home to internationally-known researchers at the forefront of cardiovascular disease research. The five-year program will support five (5) trainees slots in each year and will involve rigorous study at NCSU of statistical theory, including probability, inference, linear and other statistical models, measure theory and advanced probability, and advanced statistical inference, and statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge special topics; training in fundamental aspects of biology and cardiovascular medicine; course work in research responsibility and ethics; and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually, evolving to a full collaborative apprenticeship in which they are integrated as functioning members of DCRI project teams. Through both this apprenticeship and formal courses and seminars, trainees will develop extensive working knowledge and expertise in cardiovascular medicine that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Trainees will be assigned an inter- institutional mentorship team consisting of primary and secondary biostatistician mentors at each site and a secondary clinician mentor at DCRI, who will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees' cardiovascular disease research collaborations.