Statistic Database and Datasharing Core

该方案项目的数据库和统计核心设在人事部 加州大学洛杉矶分校医学院的遗传学。该部门包括10岁儿童的最高3层 位于贡达大厦的遗传学研究中心。它拥有一流的完全联网的计算机设施 由程序员和网络管理人员组成，通过人文部生物信息学核心 遗传学。此外，加州大学洛杉矶分校人类遗传学系已发展为其强项之一 强大的统计遗传学研究小组，专注于在 部门。其中包括康托博士、辛谢默博士、霍瓦斯·帕普博士和兰格博士。一些最新的 该小组在关联分析和数量性状连锁分析方面的软件开发是 受本计划项目当前周期产生的数据和研究问题的激励。 数据库和统计核心负责托管和维护方案项目的中央服务器。这些 包括位于专业级安全设施中专用数据库、Web和终端服务器 冷却和供电。这些机器可以访问超过42 TB的存储容量。数据已备份 每晚增量备份到一个RAID磁盘阵列，然后每个周末完全备份到一个数字磁带库。 所有服务器都维护在操作系统和应用程序软件的当前补丁级别。这些 根据计划项目的数据规模和复杂性，专用服务器是功能强大的机器。全 机器将高度安全，同时仍允许轻松访问和最大限度地延长正常运行时间。计划项目 科学家还将访问由人类遗传学维护的由40多个节点组成的计算集群 IT员工。这个计算集群有一个完整的遗传应用程序库，并不断更新 当前版本或请求的任何新程序包。 用作终端服务器的机器是一台8路Xeon 3 GHz计算机，具有16 GB的RAM。 使用标准的Windows远程桌面连接(RDC)软件。计划项目数据分析师将 通过个性化的密码，能够从任何地方通过互联网连接访问此计算机 受保护的帐户。为了获得最佳速度，所有数据分析都将在终端传感器上进行，而不是在 客户的计算机。此终端服务器和FAST数据库服务器之间有千兆连接 数据传输。通过使用Windows操作系统和应用软件的位版本， 数据分析人员几乎可以访问用于大规模数值计算的全部16 GB数据空间 康托博士、辛谢默博士、霍瓦斯博士、帕普博士和兰格博士在印度设有办公室、数据分析和计算机实验室。 这座建筑，以及帕朱坎塔、卢西斯和雷伊的实验室，所以关于设计和数据的讨论 分析范围很广，而且经常发生。以促进数据管理和统计和数据的执行 该核心使用的遗传分析、数据库以及统计和遗传分析程序包括 定期更新。此外，公开可用的基因分析程序被安装在网络上作为 它们可以通过万维网获得。数据每天都会备份。为了跟上...的步伐 当前计算技术的发展，计算机系统的硬件和软件都在升级 定期在加州大学洛杉矶分校人类遗传学系生物信息学核心。

The Database and Statistics Core of this Program Project is housed within the Department of Human Genetics in the UCLA School of Medicine. The Department encompasses the top 3 floors of the 10 year old Genetics Research Center in the Gonda Building. It has a 'state of the art' fully networked computer facility staffed by programmers and network managers through the Bioinformatics Core of the Department of Human Genetics. In addition, the UCLA Department of Human Genetics has developed as one of its strengths a substantial statistical genetics research group, focused on developing genetic analysis software within the Department. It includes Drs. Cantor, Sinsheimer, Horvath Papp, and Lange. Some of the most recent software developments in association analysis and quantitative trait linkage analysis by this group were motivated by data and research questions generated by the Program Project in its current cycle. The Database and Statistics Core hosts, and maintains the central servers for the Program Project. These include dedicated Database, Web, and Terminal servers located in a secure facility with professional-grade cooling and power. These machines have access to over 42 TB of storage capacity. The data is backed up incrementally each night to a RAID disk array and then fully backed up each weekend to a digital tape library. All servers are maintained at the current patch level of the operating system and application software. These dedicated servers are powerful machines as is required by the Program Project's data size and complexity. All machines will be highly secure while still allowing for easy access and maximum uptime. The Program Project scientists will also have access to a computational cluster of over 40 nodes maintained by the Human Genetics IT staff. This computational cluster has a full library of genetic applications, and is continually updated with current versions or any new packages that are requested. The machine used as the Terminal Server is an eight-way Xeon 3 GHz computer with 16 GB of RAM. Using standard Windows Remote Desktop Connectivity (RDC) software. Program Project data analysts will be able to access this computer from anywhere with an Internet connection, through personalized, password protected accounts. For optimal speed, all data analysis will take place on the Terminal Sen/er, not on the client's computer. There is a gigabit connection between this Terminal Server and the Database Server for fast data transfer. By using 64-bit versions of the Windows operating systems and the application software, the data analysts are assured access to virtually the full 16 GB data space for large-scale numerical computations Drs. Cantor, Sinsheimer, Horvath, Papp and Lange have offices and data analysis and computer labs in the building, along with the labs of Drs Pajukanta, Lusis and Reue, so discussions regarding design and data analysis are extensive and occur often. To facilitate data management and the performance of statistical and genetic analyses, databases and statistical and genetic analysis programs that are used by this Core are updated regularly. Additionally, publicly available genetic analysis programs are installed on the network as they become available through the worfdwide web. Data are backed up daily. In order to keep abreast of current developments in computing technologies, the computer system's hardware and software are upgraded on a regular basis in the UCLA Human Genetics Department Bioinformatics Core.