The Epidemiology of Postpartum Depression and Associated Childhood Outcomes.

描述（由申请人提供）：该项目的目的是直接回答NIMH的使命，即解决产后抑郁症的流行病学，确定相关的风险因素，并表征与临床显著的产后情绪变化相关的儿童发育和心理健康结果。产后抑郁症是生育过程中最常见的并发症(Wisner KL, Chambers C, Sit D.产后抑郁症：一个主要的公共卫生问题。JAMA 2006~296:2616-2618)，在所有新妈妈中大约有11%-19%（证据报告/技术评估119）。AHRQ出版物05-E006-2)。迄今为止，大多数关于产后抑郁症的研究都依赖于来自诊所或医院的小样本，这些样本不能产生规范的数据，并且使用不同的诊断标准，这些诊断标准往往更侧重于抑郁症的症状学，而不是抑郁症的临床诊断。这项研究建立在瑞典独特的心理健康研究资源的基础上。连接一系列瑞典登记册，包括国家病人健康和卫生服务利用登记册、国家学校登记册、

DESCRIPTION (provided by applicant): The Aims of this project are a direct answer to the mission of the NIMH to address the epidemiology of postpartum depression, to identify associated risk factors and characterize child developmental and mental health outcomes associated with clinically significant postpartum mood change. Postpartum depression is the most common complication of childbearing (Wisner KL, Chambers C, Sit D. Postpartum depression: A major public health problem. JAMA 2006~296:2616-2618), evident in approximately 11%-19% of all new mothers (Evidence Report / Technology Assessment 119. AHRQ Publication 05-E006-2). To date, most research on postpartum depression has relied on small convenience samples from clinics or hospitals that cannot generate normative data and utilize varying diagnostic criteria that more often focus on depressive symptomatology rather than clinical diagnoses of depression. This study builds on the unique resources for research on mental health available in Sweden. Linking a constellation of Swedish registers, including the National Patient Registers of health and health service utilization, National School Register, National Pharmacy Register, Total Population Register and Housing Census, we will: (a) expand upon the current knowledge base of the epidemiology of postpartum depression by more accurately describing the magnitude and pattern of clinically significant postpartum depression (hospitalized and non-hospitalized) and associated risk factors and~ (b) comprehensively characterize the child development outcomes of maternal postpartum depression. We will utilize advanced statistical methods to identify the developmental consequences of postpartum depression assessing which children of postpartum depressed mothers are more or less likely to develop problems, whether explained by maternal characteristics, such as depression timing, severity, subtypes (with and without psychosis) or comorbid conditions, child characteristics such as gender, or contextual factors such as poverty. The aims of the study are ambitious, but we have established a team of international experts with a long history of collaboration, which is well suited to address the study Aims. For predictive purposes, evaluating a comprehensive set of potential determinants of postpartum depression will generate new insights to help predict, identify, and ultimately help to prevent and treat this disorder. Because the period immediately following the birth of a child is a critica time and postpartum depression constitutes a serious threat to the infant's well-being, the epidemiologic characterization of clinically significant postpartum depression and its associated impact on childhood developmental outcomes is the first necessary step in developing adequate treatment plans.