Vulnerability to PTSD after a disaster: Clinical and public health implications

描述（由申请人提供）：在一般人群中，创伤幸存者的数量越来越多，因此，了解谁在面对创伤时会和不会发展PTSD是至关重要的。拟议中的F31研究利用了前所未有的能力，在2010年智利中部海岸发生的历史上最大的地震之一之前和之后检查PTSD。由于智利的灾难发生在现有的纵向前瞻性队列研究中，拟议的研究提供了一个难得的机会来研究位于灾难中心的成年人（N= 2，839），他们在暴露于重大创伤事件之前接受了结构化的诊断精神病学访谈。灾前轴I精神障碍（包括PTSD诊断）进行了评估，使用复合国际诊断访谈（CIDI;一个全面的完全结构化的诊断评估）。灾难发生一年后，CIDI的PTSD模块的修改版本，专门用于测量灾难中的PTSD，被管理。这提出了独特的检查PTSD的纵向过程的能力，同时检查是否灾前轴I精神障碍和历史的可管理的压力源影响的脆弱性，发展灾后PTSD或亚临床精神病学。

DESCRIPTION (provided by applicant): There are increasing numbers of survivors of trauma in the general population, therefore, it is crucial to understand who does and does not develop PTSD when faced with a trauma. The proposed F31 research takes advantage of an unprecedented ability to examine PTSD before and after one of the largest earthquakes in history that occurred in 2010 off of the central coast of Chile. As the Chilean disaster occurred i the midst of an existing longitudinal prospective cohort study, the proposed study provides a rare opportunity to study adults located at the epicenter of the disaster (N=2,839) who had undergone a structured diagnostic psychiatric interview prior to exposure to a major traumatic event. Pre-disaster Axis I psychiatric disorders (including a PTSD diagnosis) were assessed using the Composite International Diagnostic Interview (CIDI; a comprehensive fully structured diagnostic assessment). One year after the disaster, a modified version of the PTSD module of the CIDI, tailored to measure PTSD from the disaster only, was administered. This presents the ability to uniquely examine the longitudinal course of PTSD, while simultaneously examining whether pre-disaster Axis I psychiatric disorders and history of manageable stressors influence vulnerability to develop post-disaster PTSD or subclinical symptomatology.