GH12-004, S. Africa: GDD Public Health Research

描述(由申请人提供-逐字填写)： 疟疾病媒控制主要依靠使用化学杀虫剂。然而，南非目前逐步消灭和根除疟疾的努力要求开发更多的控制工具，以补充现有战略。该项目的目的是评估南非境内三项无关的疟疾病媒控制技术。主要目标是： 1.建立昆虫不育技术在南非控制疟疾媒介的可行性。这一目标的具体目的是确定实验室无菌饲养的雄性阿拉伯按蚊与其可繁殖的野生按蚊的相对交配竞争力，以及测量经辐照的雌性蚊子与未辐照的雌性蚊子相比的疟原虫传染性。 2.在南方测试白胡椒和胡椒的关键成分胡椒作为疟疾媒介幼虫的杀虫剂 非洲。 3.测定C8910对抗药性和敏感品系的驱避和杀虫性能。 。

DESCRIPTION (provided by the applicant - verbatim): Malaria vector control relies principally on the application of chemical insecticides. However, the current drive towards sequential elimination and eradication of malaria in South Africa requires that additional control tools be developed to complement existing strategies. The aim of this project is to evaluate three unrelated malaria vector control technologies within South Africa. The principal objectives are to: 1. Establish the feasibility of the sterile insect technique for malaria vector control in South Africa. The specific aim of this objective is to ascertain the relative mating competitiveness of sterile laboratory reared male Anopheles arabiensis mosquitoes compared to their fertile wild counterparts as well as to measure the Plasmodium infectivity of irradiated females compared to unirradiated females. 2. Test white pepper and piperine, a key constituent of pepper, as malaria vector larvicides in South Africa. 3. Test the repellent and insecticidal properties of C8910 against insecticide resistant and susceptible strains of malaria vector species. .