MBSR for fibromyalgia: A dose-finding study

授权：K23 AT 006703 PI：Ather Ali，ND，MPH 机构：耶鲁大学 正念干预和青少年慢性广泛疼痛 修改项目摘要/摘要部分 越来越多的证据表明，影响大量成年人的许多慢性疼痛病症（例如头痛、功能性腹痛、纤维肌痛）开始于儿童期并持续存在。最近的数据显示，很大一部分被诊断为青少年纤维肌痛/慢性广泛性疼痛的个体在成年后继续符合纤维肌痛的诊断标准。随着时间的推移，这些患者往往变得越来越残疾。年轻人群迫切需要安全、有效和耐受性良好的干预措施。 许多试验评估了各种形式的正念冥想，在成人中取得了令人鼓舞的结果，从减轻疼痛，改善身体功能，以及减少纤维肌痛成人的压痛点。然而，目前还没有针对儿童的研究，成人的成功也受到为儿科人群定制正念干预措施的挑战的影响，其中需要将依从性，可行性，父母支持和发育适当性等问题纳入方案。 K23研究的重点是开发和测试正念冥想干预青少年纤维肌痛/广泛慢性疼痛的可行性，安全性，耐受性和可接受性。本研究将为更大、更明确的R 01提交资料提供高质量数据。该项目的目标与NCCAM对治疗慢性疼痛的重视和战略计划目标一致，以“支持临床评估和身心干预的干预研究”和“支持高质量的研究培训和职业发展机会，以增加CAM研究人员的数量，质量和多样性。 除了研究，候选人将定期与他的导师和咨询委员会会面，以确保持续的进展和遵守培训，研究和职业发展计划。这将有助于确保职业发展的富有成效的时期，并提供技能、经验和指导，以便晋升为专注于慢性疼痛和综合医学干预措施的独立临床研究员。

Grant: K23 AT006703 PI: Ather Ali, ND, MPH Institution: Yale University Modified Title: Mindfulness Interventions and Chronic Widespread Pain in Adolescents Modified Project Summary/Abstract Section There is increasing evidence that many chronic pain conditions that affect large numbers of adults (e.g. headaches, functional abdominal pain, fibromyalgia) begin in childhood and persist. Recent data show that a large proportion of individuals diagnosed with juvenile fibromyalgia/chronic widespread pain continued to meet diagnostic criteria for fibromyalgia into adulthood. These patients often became increasingly disabled over time. There is a great need for safe, effective, and well-tolerated interventions for younger populations. A number of trials have assessed various forms of mindfulness meditation with promising results in outcomes in adults ranging from reduced pain, improved physical function, and fewer tender points in adults with fibromyalgia. However, there have been no studies in children and the success in adults is tempered by the challenge in tailoring mindfulness interventions for pediatric populations in which issues of adherence, feasibility, parental support, and developmental appropriateness need to be incorporated into the protocol. The focus of the K23 research is to develop and test the feasibility, safety, tolerability and acceptability of a mindfulness meditation intervention for adolescents with juvenile fibromyalgia/widespread chronic pain. This study will provide high-quality data for a larger, more definitive R01 submission. The goals of this project are consistent with NCCAM's emphasis on treating chronic pain and Strategic Plan goals to “support clinical evaluation and intervention studies of mind/body interventions” and “support high-quality research training and career development opportunities to increase the number, quality, and diversity of CAM researchers.” In addition to the research, the candidate will regularly meet with his mentor and advisory committee to ensure consistent progress and adherence to the training, research, and career development plan. This will help ensure a productive period of career development, and provide the skills, experience, and guidance in order to advance to an independent clinician-researcher focused on chronic pain and integrative medicine interventions.