Molecular Biology and Gene Therapy in Burns and Trauma

这个现有的培训计划的总体目标是提供一个集中的2-3年的研究经验， 临床实习医生在培训（主要是在外科）表达了对创伤，损伤，烧伤或 炎症研究。该研究计划将侧重于掌握分子生物学，功能基因组学和 基因疗法，因为它适用于炎症研究。该计划将利用的独特优势， 医学院在功能基因组学，基因治疗和分子生物学的不断扩大的领域，以及 基础科学家和临床医生之间的合作，致力于培养未来的临床学者。的 分子生物学和炎症研究之间接口将针对ARDS，脓毒症综合征， 缺血/再灌注损伤，延迟伤口愈合和烧伤，教师将从资助的基础 外科、妇产科、分子遗传学和微生物学部门的科学家，他们将 担任学员的研究导师。来自外科、麻醉学、医学和病理学的临床导师 各部门将与受训人员和研究人员互动，以确保受训人员接触到 炎症研究中的临床重要问题。该计划的总体方向将取决于校长 调查员和执行委员会。研究金候选人将在全国范围内征聘， 佛罗里达大学医学院。成功的申请人与执行委员会将确定一项研究 和临床导师，他们将帮助制定正式的培训计划，并定期审查受训者的进展。的 大部分培训计划将在一位经验丰富的研究导师的实验室中进行，但学员也将 要求完成研究伦理和统计方法的基础课程工作，并将鼓励获得 分子生物学的补充教学培训，利用博士学位提供的方案，如果 适当的..此外，预计受训人员将参加鲍威尔基因治疗中心的研讨会， 遗传研究所，并在其基础科学部门，以及实验室研究会议。他们还将 预计参加临床研讨会，包括外科和重症监护医学大查房。预计各国 成功的毕业生将具备足够的研究技能，以竞争炎症研究的过渡资金。 相关性（参见说明）： 社会认识到临床科学家在转化生物学和新的生物技术应用中发挥的关键作用。 技术到诊所。我们建议，一个年轻的有兴趣的临床医生在实验室的2-3年的浸泡， 具有分子生物学专业知识成功的基础科学家将为作为 参与转化研究的医生/科学家。成功的受训者将具备职能方面的专业知识， 基因组学，基因治疗和分子生物学，以帮助翻译目前的遗传革命创伤的做法。

The overall goal of this existing training program is to provide a focused 2-3 year research experience for up to two clinical residents-in- training (predominantly in surgery) expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy, as it applies to inflammation research. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics, gene therapy and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. The interface between molecular biology and inflammation research will be targeted to ARDS, sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, The faculty will be drawn from funded basic scientists in the Surgery, Obstetrics/ Gynecology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Anesthesiology , Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology, taking advantage of Ph.D. programs available to them, if appropriate.. Furthermore, trainees are expected to participate in seminars in the Powell Gene Therapy Center and Genetics Institute, and in their basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research. RELEVANCE (See instructions): Society recognizes the critical role that clinician-scientists play in translational biology and the application of new technologies to the clinic. We propose that a 2-3 year immersion by a young interested clinician in the laboratory of a successful basic scientist with expertise in molecular biology will provide a sound foundation for a career as a physician/scientist involved in translational research. The successful trainees will have the expertise in functional genomics, gene therapy and molecular biology to help translate the current genetic revolution to trauma practice.