Training in Molecular Therapeutics for Pediatric Cardiology

描述（申请人提供）：该培训项目为学术临床医生提供为期两年的血管外科基础研究培训。它解决了血管外科医生缺乏足够的研究培训，因为它适用于临床疾病的特定领域。在分子和细胞生物学、生物力学、凝血血栓形成和血管生成方面的研究培训，重点是临床相关问题，如动脉粥样硬化、内膜增生、假体/宿主相互作用和血栓形成。一个新的组成部分是有指导的高级成果研究培训的可用性。受训者进行密集的研究活动计划，并辅以研究设计、统计和已发表研究的评估课程。该项目由项目主任、副主任和导师进行并密切监督，他们在同行评审的研究中有着良好的记录，他们被选中进行当前的研究活动，并证明了他们对培养研究人员的承诺。根据学员个人的背景和研究兴趣，从项目的教师中选择个人导师，学员在导师的密切指导下开展自己的项目。在哈佛医学院、卫生保健政策与研究部和哈佛文理学院的研究生水平培训可以作为实验室培训的补充，课程选择也可以作为实验室工作的补充。完成课程后，学员将具备独立研究的能力，并具备获得有竞争力的同行评审资助所需的科学和研究背景；他们有能力和知识提供必要的转化专业知识，因为他们加入医学院的院系。学员的选拔是基于候选人的展示能力和学术实践的职业选择。申请人须为完成两年、三年或五年（即符合委员会资格）的外科研究生培训的住院医师。学员承诺接受两年的培训；希望缩短培训时间的学员不予考虑。只有以学术外科为职业目标，对血管外科基础研究或成果研究有浓厚兴趣的申请人，才可申请。在临床培训项目中攻读奖学金的候选人必须提供证据，证明他们在完成研究培训后将被接受回到该项目。除非与研究有关，受训者不得参与任何临床活动。相关性（见指南）：血管外科医生为血管设备和干预的相关问题提供实用的“动手”视角。该项目培养了一批具有研究基础知识的外科医生，这些专业知识对治疗血管疾病的前线“从工作台到病床再到公共政策”项目至关重要。

Description (provided by applicant): This training program provides two years of basic research training in vascular surgery for academic clinicians. It addresses the absence of adequate research training for vascular surgeons as it applies to specific areas of clinical disease. Research training in molecular and cell biology, biomechanics, coagulation thrombosis, and angiogenesis is provided with a focus on clinically relevant problems such as atherogenesis, intimal hyperplasia, prosthetic/host interactions and thrombosis. A new component is the availability of mentored advanced outcomes research training Trainees pursue a program of intense research activity supplemented with course work in research design, statistics, and evaluation of published research. The program is conducted and closely supervised by the program director, co-director and mentors who have well-established records of peer-reviewed research, and who were selected both for the current research activities and their proven commitment to train research fellows. Individual mentors are chosen from the program's faculty on the basis of the background and research interest of the individual trainee, and the trainees carry out their own projects under the close guidance of their mentor. Laboratory training can be supplemented by graduate level training at Harvard Medical School the Department of Health Care Policy and Research and Harvard's Faculty of Arts and Sciences, with course selection complementing laboratory endeavors. Upon completion of the program, trainees are capable of independent research and possess the scientific and research background needed to obtain competitive peer-reviewed grants; they have the abilities and knowledge necessary to provide translational expertise as they join medical school faculties. Selection of the trainees is based on candidates' demonstrated ability and career choice of academic practice. Applicants are resident physicians who have completed two, three or five years (i.e. is board eligible) of post-graduate surgical training. Trainees commit to two years of training; trainees desiring a shorter training period are not considered. Only those applicants with career goals in academic surgery, with a keen interest in basic resarch or outcomes research in vascular surgery, are compatible. Candidates pursuing a fellowship during a program of clinical traning must provide evidence that they will be accepted back into that program upon completion of their research training. Trainees are not involved in any clinical activities unless research related. RELEVANCE (See instructions): Vascular Surgeons provide a practical "hands on" perspective on the relevant problems of devices and interventions on blood vessels. This program creates a cadre of surgeons with expertise in research fundamentals essential to frontline 'bench to bedside to public policy' programs in treatment of vascular disease.