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Eukaryotic Heme Utilization

Eukaryotic Heme Utilization
真核血红素利用
批准号：
8939623
负责人：
Caroline Philpott
金额：
$7.76万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8939623
关键词：
BindingBiochemicalBiologicalCellsCopperCytosolEnvironmentEnzymesEukaryotaFriedreich AtaxiaGenesGeneticHemeHeme IronHemoglobinHereditary DiseaseHereditary hemochromatosisHomeostasisHumanIntracellular TransportIronIron CompoundsIron OverloadMammalsMetabolismMitochondriaMyoglobinNutrientOrganic Iron CompoundsOrganismOxygenProcessRegulationRoleSaccharomyces cerevisiaeSaccharomycetalesSystemToxinYeastsZincaqueouscofactordeprivationheme ahuman diseaseinsightiron metabolismmetal metabolismmicroorganismresponsetraffickinguptake

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中文摘要
翻译
人们对真核生物中的血红素转运知之甚少，酵母中也没有鉴定出一种特定的血红素转运系统。血红素是在线粒体中合成的，但辅因子在整个细胞的隔间中使用。血红素是高度疏水的，不太可能被释放到胞浆的水环境中，这表明存在着血红素在细胞内运输的机制。我们目前正在表征人类线粒体血红素出口商FLVCR1b的血红素外流活性。
英文摘要
Very little is known about heme transport in eukaryotes and a heme-specific transport uptake systems have not been identified in yeast. Heme is synthesized in mitochondria, yet the cofactor is used in compartments throughout the cell. Heme is highly hydrophobic and is unlikely to be released into the aqueous environment of the cytosol, suggesting that mechanisms exist for the intracellular trafficking of heme. We are currently characterizing the heme efflux activity of the putative mitochondrial heme exporter of humans, FLVCR1b.
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Eukaryotic Heme Utilization
Identification of human genes of iron homeostasis
Cell Biology of Iron Transport
Eukaryotic Heme Utilization
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