2014 AAOS/CORR/ORS/CMH-UCD Musculoskeletal Sex Differences Throughout the Lifespa

描述（由申请人提供）：男性和女性之间肌肉骨骼疾病、病症和运动损伤的发生率和严重程度差异是固有解剖学、生物力学、激素和细胞/分子差异的结果。对治疗的反应（例如，手术、麻醉、止痛药、药物和康复）也因性别而异，但所涉及的机制尚未得到很好的描述，也没有与临床观察相关联或向临床受众传播。例如，大多数骨质疏松症患者是女性，而大多数由创伤或运动损伤引起的疾病发生在男性中。许多关于肌肉骨骼疾病治疗的研究都涉及使用年轻的成年动物，并且由于一些实验原因，这些动物在骨质疏松症的情况下是雌性的，而在治疗的情况下是雄性的。因此，我们对这些情况的理解，因为他们在整个生活中，并为其他性别，是有限的。2014年AAOS/CORR/ORS/CMH-UCD肌肉骨骼性别差异在整个生命周期的研究研讨会和随后的出版物将带来基础科学家和工程师与临床医生谁治疗肌肉骨骼患者在护理的各个阶段，讨论如何在生物力学性别差异的理解进展，生物学和生理学影响肌肉骨骼健康和患者结果，以确定与整个生命周期中的性和性别问题有关的新研究领域。研讨会将包括由各自领域的领导者介绍当前的技术水平，然后进行小组讨论，以确定知识差距并确定未来的研究方向。

DESCRIPTION (provided by applicant): Differences in the incidence and severity of musculoskeletal diseases, conditions, and sports injuries between males and females are the result of inherent anatomic, biomechanical, hormonal, and cellular/molecular differences. Responses to therapy (e.g., surgery, anesthesia, pain medication, pharmaceuticals, and rehabilitation) also differ by sex, but the mechanisms involved have not been well described, nor have they been correlated with clinical observations or disseminated to clinical audiences. For example, the majority of osteoporosis patients are female, and the majority of disorders caused by trauma or sports injuries occur in males. Much of the research on therapies for musculoskeletal disorders has involved the use of young adult animals, and for a number of experimental reasons, these animals have been female in the case of osteoporosis and male in the case of therapeutics. As a result, our understanding of these conditions as they present throughout life, and for the other sex, is limited. The 2014 AAOS/CORR/ORS/CMH-UCD Musculoskeletal Sex Differences Throughout the Lifespan research symposium and subsequent publication will bring basic scientists and engineers together with clinicians who treat the musculoskeletal patient at all stages of care to discuss advances in the understanding of how sex differences in biomechanics, biology and physiology impact musculoskeletal health and patient outcomes in order to identify new areas of research related to sex and gender issues over the entire lifecycle. The symposium will include presentations by leaders in their respective fields addressing the current state of the art, followed by group discussions to identify knowledge gaps and identify future research directions.