Cellular and molecular foundations of biomedical science

描述(申请人提供)：这项关于“生物医学科学的细胞和分子基础”的培训拨款提案是对11年前开始的一个成功项目的更新。它寻求在生物医学科学的广泛基础上培训研究生，为他们提供工具来理解现代生物学和健康中的重要问题。这首先是通过第一年的核心课程模块完成的，内容包括遗传学、分子生物学、结构生物学、生物物理学、细胞生物学和基因组学和系统生物学。学生在此基础上选修他们感兴趣的特定领域的课程。该项目以生物科学系为基础，但已扩大到哥伦比亚大学内科和外科学院的现有教员以及化学系的教员。学生们在最多三个实验室轮流工作，可以与该项目55名教职员工中的任何一人一起完成论文工作，大约一半的教职员工分别在医学院和主校区。这为优秀实验室的学生提供了更多的培训机会，并促进了哥伦比亚大学医学院和主校区师生之间的合作。该学院的工作领域广泛，包括结构生物学、分子生物学、微生物学、遗传学、生物信息学和系统生物学、发育生物学和神经生物学。实验系统也很广泛，包括细菌、酵母、果蝇、线虫、青蛙和老鼠。人体组织培养系统也被利用，大多数系统考虑与人类健康和生理相关的问题。每年需要10个研究生实习生职位，以支持5名学生，每个为期两年，通常是在他们的第三和第四年。这将为我们目前69名符合培训资助资格的学生提供14.5%的资金。我们项目中最优秀的学生将由这笔助学金资助。这将取决于他们在核心课程和其他课程中的表现，他们的轮换和论文赞助商的建议，以及由基金指导委员会审查的简短研究提案。哥伦比亚大学的师资和研究设施非常优秀，为学生提供了一流的培训环境。学生优秀出版物的记录也证明了这个项目的成功。

DESCRIPTION (provided by applicant): This training grant proposal on the "The cellular and molecular foundations of biomedical sciences" is a renewal of a successful program started eleven years ago. It seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through Core course modules in the first year covering Genetics, Molecular Biology, Structural Biology, Biophysics, Cell Biology and Genomics and Systems Biology. Students follow this with electives in specific fields of their interest. The program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons as well as faculty in the Department of Chemistry. Students undertake rotations in up to three laboratories and can do their thesis work with any of the 55 faculty in the program, roughly half of which are on the Medical School and Main campuses, respectively. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty work in a broad range of fields including structural biology, molecular biology, microbiology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relevant to human health and physiology. Ten graduate student traineeships are requested per year to support five students for two years each, usually in their third and fourth years. This will fund 14.5% of our current training grant eligible student pool of 69. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provide a superb training environment for the students. The record of outstanding publications by the students also demonstrates the success of this program.