Mentoring and Research in Placebo Studies, Asian Medicine, and CAM

描述（由申请人提供）：四年前，Kaptchuk教授，OMD，获得了职业中期K24奖。这是一份更新申请。主要研究者的短期目标是获得受保护的时间，以1）稳定和扩大他对下一代CAM科学家的培训，2）开发安慰剂，东亚医学和补充和替代医学（CAM）的多学科研究计划。他的长期目标，为他的工作和他的学员，是作出临床相关的贡献，临床护理。特德·卡普切克是哈佛医学院的医学副教授。他的研究和奖学金整合了基础，临床和社会科学以及人文科学的概念，研究设计和分析方法。K24前四年的成就：主要研究者已经完成了三项主要的RCT研究安慰剂效应和两项RCT测试针灸的疗效。他还进行了开创性的研究，确定了对安慰剂和针灸反应的大脑回路。在此期间，主要研究者发表了70篇文章，其中8篇为第一作者，28篇为高级作者。主要研究者还收到了两份新的R 01，涉及安慰剂/预期效应和针灸，作为高级合作研究者，还收到了P01、U19和各种R21。 在最初的K24期间，他曾为25名拥有博士学位的学员担任主要或共同主要的CAM导师。11名学员获得K培训奖。他的学员撰写了53篇第一作者的同行评审出版物，并有82篇合著。他希望在更新期内扩大这些成功的努力。哈佛大学及其17所教学医院组成了一个隶属于NIH的CTSA机构联盟。Kaptchuk教授完全融入了CTSA，最近被任命为安慰剂研究和治疗接触的哈佛计划主任。他积极参与许多哈佛奖学金项目，包括担任哈佛大学资助的NCCAM T32 CAM奖学金项目的副主任。主要研究者将参加生物伦理学、科学哲学、免疫学和统计学方面的相关课程，并参加分子和神经影像学研究方面的实践培训。 在他的K24的前四年，首席研究员开发了一个研究组合，其中包括肠易激综合征，哮喘，抑郁症，骨关节炎和偏头痛的转化研究。这些研究领域将进一步扩大。他目前正在使用功能磁共振成像技术，将他之前在健康志愿者中进行的安慰剂和针灸神经回路的研究扩展到慢性疼痛障碍患者。PET-fMRI研究将研究依赖于吗啡条件作用与酮咯酸条件作用的安慰剂反应。他将启动功能性磁共振成像实验，以阐明患者-医生关系中医生组成部分的神经生物学。主要研究者还通过同时检查循环血清细胞因子，自身抗体，microRNA和相关基因的多态性（SNP）来研究安慰剂和针灸反应中涉及的特定生物学途径及其调节机制。

DESCRIPTION (provided by applicant): Four years ago, Professor Kaptchuk, OMD, received a Midcareer K24 award. This is a renewal application. The principal investigator's short-term goal is to obtain protected time to 1) stabilize and expand his training of the next generation of CAM scientists and 2) develop a multi-disciplinary research program in placebo, East Asian medicine and complementary and alternative medicine (CAM). His long-term goal, for his work and that of his trainees, is to make clinically relevant contributions to clinical care. Ted Kaptchk is Associate Professor of Medicine at Harvard Medical School. His research and scholarship integrates concepts, research designs and analytic methods drawn from the basic, clinical, and social sciences, as well as the humanities. Achievements in first four years of K24: The principal investigator has completed three major RCTs investigating placebo effects and two RCTs testing acupuncture's efficacy. He also performed groundbreaking studies identifying the brain circuitry of responses to placebo and acupuncture. In this period, the principal investigator published 70 articles, eight as first author and 28 as senior author. The principal investigator also received two new R01s concerned with both placebo/expectation effects and acupuncture and, as senior co-investigator, a P01, U19 and various R21s. During the initial K24 period, he has been primary or co-primary CAM mentor for 25 trainees with doctoral degrees. Eleven trainees held K training awards. His trainees authored 53 first-authored peer-reviewed publications and had 82 co-authorships. He expects to expand these successful efforts in a renewal period. Harvard University and its 17 teaching hospitals comprise an NIH affiliated CTSA institutional consortium. Professor Kaptchuk is fully integrated into the CTSA and has recently been appointed director of Harvard-wide Program in Placebo Studies and Therapeutic Encounter. He is active in many Harvard fellowship programs including serving as associate director of the Harvard-wide NCCAM-funded T32 CAM fellowship program. The principal investigator will take relevant courses in bioethics, philosophy of science, immunology, and statistics and engage in hands-on training in molecular and neuroimaging research. In the first four years of his K24, the principal investigator developed a research portfolio that includes translational research in irritable bowel syndrome, asthma, depression, osteoarthritis, and migraine. These research areas will be expanded. He is currently using fMRI to extend his previous work on the neural circuitry of placebo and acupuncture in healthy volunteers to patients with chronic pain disorders. A PET-fMRI study will investigate placebo responses dependent on morphine conditioning verses ketorolac conditioning. He will initiate fMRI experiments to elucidate the neurobiology of the physician component of the patient-physician relationship. The principal investigator is also investigating specific biological pathways implicated in placebo and acupuncture responses and their mechanisms of regulation by concurrently examining circulating serum cytokines, auto antibodies, microRNAs and polymorphisms (SNPs) in genes of interest.