An Integrative Healing Model in IBS

描述(由申请人提供)： 根据这一奖项召集的网络将包括来自五个学科领域的专家：i)安慰剂反应研究，ii)遗传学，iii)社会流行病学，iv)压力生理学，v)医学人类学。此外，还将包括生物统计学、多层次建模和胃肠病学方面的专家。主要目的是促进这些学科领域的概念、研究设计和分析方法的整合，以研究肠易激综合征(IBS)的康复。第一年将包括对五个领域中每一个领域的相关研究的审查，对正在进行的随机对照试验“IBS的安慰剂效应”的假设、设计和分析计划的审查，关于另外两个学科领域中因素之间相互作用的额外假设的制定，相关变量的确定，以及多水平分析模型的制定。它还将包括关于来自不同领域的定性和定量变量之间相互作用的假设的提出，相关变量的确定，以及整合其分析的方法。在第二年，将提供正在进行的区域审评的数据集，以测试和改进多层次模型以及定性-定量分析模型。这些数据包括每个学科领域关于该试验参与者治疗反应的定量和定性数据。在第二年，将继续改进和测试多层次分析模型以及定性-定量分析模型。最后，网络参与者的小组将起草IBS和其他类似障碍治疗领域的跨学科研究设计。在该奖项的两年期间，该网络将举行四次会议，并将举行十二次视频会议。研究文件和数据将通过一个安全的网络存储站点存档和分发。演出地点将是哈佛医学院奥舍研究所。主要人员是Ted Kaptchuk、OMD(PI)、Lisa Conball、ScD、Catherine Kerr、Phd、Eric Jacobson、Phd、Anthony Lembo、MD、Denesh Chitkara、MD、Eric Loucks、Phd、Dolores Acevedo-Garcia、Phd、Byron Good、Mary-Jo Delvicchio-Good、PhD、Tom Csordas、PDD、Nick Tley、MD、PhD、Jarvis Chen、ScD、Bonghyun nam、PhD和VC Subramanian博士。

DESCRIPTION (provided by applicant): The network convened under this award will include experts from five disciplinary areas: i) studies of placebo response, ii) genetics, iii) social epidemiology, iv) stress physiology, and v) medical anthropology. In addition experts in biostatistics, multi-level modeling, and gastroenterology will also be included. The primary aim is to advance the integration of concepts, research designs and analytic methods from these disciplinary areas for the study of healing in Irritable Bowel Syndrome (IBS). Year One will include a review of relevant research in each of the five areas, a review of the hypotheses, design and analytic plans from an ongoing RCT "Placebo Effect in IBS," the formulation of additional hypotheses as to interactions between factors in two more of the disciplinary areas, the identification of relevant variables, and the formulation of multi-level analytic models. It will also include the formulation of hypotheses as to interactions between qualitative and quantitative variables from different areas, identification of relevant variables, and methods of integrating their analysis. In Year Two data sets from the ongoing RCT will be made available for the purpose of testing and refining the multi-level models, and the models of qualitative-quantitative analysis. These include quantitative and qualitative data from each of the disciplinary areas on the therapeutic response of participants in that trial. In Year Two the refinement and testing of multi-level analytic models, and of models of qualitative-quantitative analysis will continue. Finally, sub-groups of network participants will draft interdisciplinary research designs in the areas of healing in IBS and other similar disorders. During the two years of the award the network will meet four times and will video-conference twelve times. Study documents and data will be archived and distributed via a secure web storage site. The Performance Site will be Osher Institute, Harvard Medical School. Key Personnel are Ted Kaptchuk, OMD (PI), Lisa Conboy, ScD, Catherine Kerr, PhD, Eric Jacobson, PhD, Anthony Lembo, MD, Denesh Chitkara, MD, Eric Loucks, PhD, Dolores Acevedo-Garcia, PhD, Byron Good, PhD, Mary-Jo Delvicchio-Good, PhD, Tom Csordas, PdD, Nick Talley, MD, PhD, Jarvis Chen, ScD, Bonghyun Nam, PhD, and VC Subramanian, PhD.