Translating discoveries in neurological diseases of infancy and childhood

描述（由申请人提供）：这个竞争性的更新应用程序的目标是继续培训，以最高的严谨性，候选人谁将在学术儿童神经学取得成功。在UCSF，我们创建了一个将临床重点与严格的研究生科学培训相结合的项目。在过去的二十年里，NSADA为我们的儿童神经病学部门提供了学术发展的基础，并使我们能够将临床培训与科学发现相结合。UCSF最近的变化将进一步加强我们的计划。2011年成立的UCSF儿科脑中心打破了传统的孤岛，促进了跨学科临床医生和科学家之间的合作。237，000平方英尺的桑德勒神经科学中心于2012年在UCSF使命湾校区开放，将神经病学，神经外科和精神病学的研究人员聚集在一个屋檐下。新的加州大学旧金山分校贝尼奥夫儿童医院将于2015年2月在同一校园开放，距离桑德勒大楼仅几步之遥，并且已经引发了桑德勒研究人员之间关于儿童疾病的新合作。我们申请的总体主题是，“翻译婴儿和儿童神经疾病的发现。“我们将为年轻的研究人员提供严格的研究方法培训，这些年轻的研究人员具有集中的临床专业知识，他们准备在儿童神经病学的各自领域中确定最紧迫的研究问题。我们的具体目标是继续提供一个结构化的计划，培训学术儿童神经学家的职业生涯在转化研究;促进职业发展，配对临床 和研究兴趣;使候选人接触UCSF的智力环境;并促进学术儿童神经病学的多样性。该计划的计划持续时间为5年;我们计划培训3名学者，他们将是最近完成临床亚专业培训的初级教师。我们的第一位候选人Kevin Shapiro，医学博士，博士，是一位儿童神经学家和认知心理学家，目前正在完成血管神经学奖学金。他将研究语言发展和皮质可塑性后，早期脑损伤使用认知测试和多模式神经影像学相结合的儿童局灶性缺血性脑病变。他将受益于两位国际公认的导师：语言障碍专家玛丽亚·路易莎·戈尔诺·滕皮尼博士和儿童中风专家石楠·富勒顿博士。他将使用桑德勒的设施，包括神经科学成像中心，这是桑德勒神经科学中心一楼最先进的研究成像中心;他的导师都在同一栋楼里有他们的实验室。其他潜在候选人将提交方案供审查 我们将通过内部和外部顾问进行宣传，以提高候选人的多样性。随着完善的，国家认可和支持的培训计划在UCSF支持这个程序的教学阶段，再加上一个团队的成就导师致力于儿童神经学家的职业发展，我们将成功地带来了学术儿童神经学的下一代领导者。

DESCRIPTION (provided by applicant): The goal of this competing renewal application is to continue to train, with the highest rigor, candidates who will succeed in academic child neurology. At UCSF, we have created a program that combines clinical focus with rigorous postgraduate scientific training. Over the past two decades, the NSADA has provided the foundation for our division of child neurology to grow academically and has allowed us to merge clinical training with scientific discovery. Recent changes at UCSF will further enhance our program. The creation of the UCSF Pediatric Brain Center in 2011 has broken down traditional silos to foster collaboration between clinicians and scientists across disciplines. The 237,000 square foot Sandler Neurosciences Center opened on the UCSF Mission Bay Campus in 2012, bringing investigators in neurology, neurosurgery, and psychiatry together under a single roof. The new UCSF Benioff Children's Hospital will open on the same campus in February, 2015, steps away from the Sandler building, and is already sparking new collaborations on childhood diseases among Sandler investigators. The overall theme of our application is, "Translating discoveries in neurological diseases of infancy and childhood." We will offer rigorous training in research methodology to young investigators with focused clinical expertise who are poised to identify the most pressing research questions in their respective fields within child neurology. Our specific aims are to continue to offer a structured program for training academic child neurologists for a career in translational research; to foster career development, pairing clinical and research interests; to expose candidates to the intellectual environment of UCSF; and to promote diversity in academic child neurology. The planned duration of the program is 5 years; we project training 3 scholars who will be junior faculty having recently completed their clinical subspecialty training. Our first candidate, Kevin Shapiro, MD, PhD, is a child neurologist and cognitive psychologist who is currently completing a vascular neurology fellowship. He will study language development and cortical plasticity after early brain injury using a combination of cognitive testing and multimodal neuroimaging in children with focal ischemic brain lesions. He will benefit from two internationally-recognized mentors: Dr. Maria Luisa Gorno-Tempini, expert in language disorders, and Dr. Heather Fullerton, expert in childhood stroke. He will use Sandler facilities, including the Neuroscience Imaging Center, a state-of-the-art research imaging center on the ground floor of the Sandler Neurosciences Center; his mentors both have their laboratories in the same building. Additional potential candidates will submit protocols for review by the internal and external advisors; we will perform outreach to enhance the diversity of our candidates. With well-established, nationally recognized and supported training programs at UCSF to support the didactic phase of this program, coupled with a team of accomplished mentors committed to the career development of child neurologists, we will succeed in bringing forth the next generation of leaders in academic child neurology.