Biospecimen and Pathology Core

生物标本和病理核心（Core B）是所有Penn/Wistar孢子在皮肤癌活动中的关键。它充分利用了宾夕法尼亚大学/Wistar的基础设施，并解决了所有孢子项目中黑色素瘤患者生物标本的研究需求，这些需求目前在这些机构的共享设施中无法满足。样品的采购、处理、储存、质量控制、组织病理学评估和分配的标准化程序将确保根据组织和资源分配委员会制定的指南，对有限的组织样品进行最佳利用和分配。除了收集、储存和分发广泛的生物标本外，Core还维护一个全面的组织数据库（Labvantage LIMS数据库），其中包括详细的病理特征和必要的临床数据，包括家族史、患者当前的治疗方法、组织类型、储存组织的数量、与每个收集的标本（组织或血液）相关的分布日志，以及从这些生物标本中产生的分子（或其他分析）研究结果。与生物统计核心的密切关系将允许对不同孢子项目产生的数据进行有效分析。核心小组的领导将由一名在黑色素瘤诊断和转化研究（包括组织病理学评估、分子分析和质量控制程序）方面具有专长的资深皮肤病理学家，以及一名在组织收集、数据库设计和生物信息学方面具有专长的资深病理学家共同担任。核心与每个项目的研究人员广泛互动，并共享宾夕法尼亚大学/威斯达癌症中心的设施。核心B的服务以具有成本效益的方式提高了SPORE研究人员转化研究的有效运作，并加快了实验室发现对临床实践的应用，以及临床结果对基础研究的应用。

The Biospecimen and Pathology Core (Core B) is crucial for all Penn/Wistar SPORE in Skin Cancer activities. It fully utilizes the infrastructures at the Penn/Wistar and addresses research needs for melanoma patient biospecimens of all the SPORE projects that are not met by current shared facilities at these institutions. Standardized procedures for procurement, processing, storage, quality control, histopathologic evaluation and distribution of samples will ensure optimal utilization and distribution of limited tissue samples according to the guidelines established by the Tissue and Resource Allocation Committee. In addition to collecting, storing and distributing a wide range of biospecimens, the Core maintains a comprehensive tissue database (Labvantage LIMS database) that includes detailed pathologic characteristics and essential clinical data including family history, current therapies of patients, tissue type, amount of stored tissue, distribution log associated with each collected specimen (tissue or blood), and results of molecular (or other analytic) studies generated from these biospecimens. The close relationship with the Biostatistics Core will allow for efficient analysis of the data produced by the different SPORE projects. Leadership for the Core will be shared by a senior dermatopathologist with expertise in melanoma diagnosis and translational research, including histopathologic evaluation, molecular analysis and quality-control procedures as well as a senior pathologist with expertise in tissue collection, database design and bioinformatics. The core interacts extensively with investigators in each project, and shared facilities of the Penn/Wistar Cancer Centers. The services of the Core B enhance the efficient operation of the translational studies by SPORE investigators in a cost-effective manner, and expedite the application of discoveries at the bench to clinical practice, and clinical results to basic research.