Laboratory Animal Medicine and Translational Research Training for Veterinarians

描述(申请人提供)：涉及使用复杂动物模型的生物医学研究的稳步增长导致需要训练有素的实验动物兽医来管理、指导和提供临床和监管支持。此外，兽医是研究团队的重要成员，因为他们在全动物生物学、病理学和外科手术方面接受了独特的比较培训。这项建议的总体目标是在实验动物医学和研究方法方面再培训3名研究生兽医，具体目标是为未来的职业生涯培养优秀的实验动物兽医。 在学术界、工业界和教育界。培训时间为动物医学临床实验室2年，研究方法1年(共培训3年)。华盛顿大学(UW.)由于其在联邦研究资助方面排名第一(2010年排名第二的公立大学)，相关的华盛顿国家灵长类动物研究中心(WaNPRC)和水产和渔业科学学院，当地大型生物技术社区(Amgen Inc.，ZymoGenetics Inc.等)，以及在高度协作的环境中成功培训实验室动物兽医的悠久而28年的历史，该公司处于实现这些目标的理想地位。这项建议的具体目标是：(1)培训兽医科学家在生物医学和行为研究中使用的动物疾病的生物学、护理和治疗、检测和预防方面的知识。我们将利用教学课程和轮换课程，通过U.W.比较医学系(DCM)和WaNPRC管理的动物设施、U.W.动物福利办公室(OAW)、预防医学和职业健康与安全计划、转基因资源和当地生物技术公司，提供通过美国实验动物医学院(ACLAM)认证的深入实验室动物医学培训；(2)在生物医学研究方法方面培训兽医科学家，重点是涉及小鼠或非人类灵长类模型的翻译研究。兽医参与者将在DCM或WaNPRC实验室进行基于假设的研究，目标是发表一篇同行评议的手稿，以获得ACLAM委员会考试的资格。研究培训和教学课程将集中在利用基因工程小鼠(GEM)和非人类灵长类动物在免疫学、传染病、行为、癌症和衰老研究中的翻译应用。这些目标将确保威斯康星大学实验动物医学毕业生接受过高度培训，以获得ACLAM委员会认证；满足国家的生物医学、行为和临床需求；并成为成功的合作研究科学家。

DESCRIPTION (provided by applicant): The steady growth of biomedical research involving the utilization of complex animal models has resulted in a need for highly trained laboratory animal veterinarians to manage, direct, and provide clinical and regulatory support. In addition, veterinarians are essential members of research teams due to their unique, comparative training in whole-animal biology, pathology, and surgery. The overall goal of this proposal is to train 3 additional post-graduate veterinarians in laboratory animal medicine and research methodology with the specific objective of preparing exceptional lab animal veterinarians for potential careers in academia, industry, and teaching. The duration of training will be 2 years of clinical laborator animal medicine, and 1 year of research methodology (3 years total training). The University of Washington (U.W.) is ideally positioned to accomplish these goals, due to its top-ranking in Federal Research Funding (#2 Funded Public University in 2010), associated Washington National Primate Research Center (WaNPRC) and School of Aquatic and Fishery Sciences, large local biotechnology community (Amgen Inc, ZymoGenetics Inc, etc), and long, 28 year history of successfully training laboratory animal veterinarians in a highly collaborative environment. The Specific Aims of this proposal are: (1) To train veterinary scientists in the biology, care, and treatment, detection, and prevention of disease in animals used in biomedical and behavioral research. We will utilize didactic courses and rotations through the U.W. Department Comparative Medicine (DCM) and WaNPRC- managed animal facilities, U.W. Office of Animal Welfare (OAW), Preventative Medicine and Occupational Health and Safety Programs, Transgenic Resources, and local biotechnology companies to provide in-depth Lab Animal Medicine training certified by the American College of Laboratory Animal Medicine (ACLAM); (2) To train veterinary scientists in biomedical research methodology, with emphasis on translational research involving mice or non-human primate models. Veterinary participants will perform hypothesis-based research in DCM or WaNPRC laboratories, with the goal of publishing a peer-reviewed manuscript to qualify for the ACLAM-board examination. Research training and didactic courses will focus on translational applications of utilizing genetically engineered mice (GEM) and non-human primates in Immunology, Infectious Disease, Behavior, Cancer, and Aging research. These Aims will ensure that U.W. Laboratory Animal Medicine graduates are highly-trained to become ACLAM-board certified; to address the Nation's biomedical, behavioral, and clinical needs; and to serve as successful collaborative research scientists.