Magnetic resonance spectroscopy (MRS)

MRS结合[13]C同位素标记底物是唯一一种对细胞特定能量和神经递质代谢进行脑部成像的非侵入性方法。然而，神经科学家对MRS的应用受到了陡峭的学习曲线和技术障碍的阻碍，其中包括需要大量的资源和专业知识集中。在上一个周期中。核心2实施并支持使用各种最先进的MRS方法，并结合磁共振成像(核心1)和神经生理学记录(核心3)结合具体项目的数据分析(核心4)对MRS进行综合研究。通过招募新用户以及支持和培训。CORE 2现在支持由NINDS资助的7个合格PIS的工作，NINDS与其他16个NIH资助的PIS一起使用多核MRS来解决基础和临床神经科学中的基本问题。核心2的影响进一步表现在对26项NIH拨款和3项新研究倡议的支持，这些工作导致了ROI拨款，培训了5名神经科学家使用MRS方法，并为50篇论文做出了贡献，导致了604次引用(仅就核心2而言，这就占了106篇核心论文总引文的50%)。在下一个周期，我们将继续为Core 2用户实施、维护和支持创新的多核MRS方法，支持新的研究计划，为神经科学PI及其工作人员在Core 2使用方面提供培训和指导，整合MR/神经生理测量和特定项目数据分析的协同使用，实施新的Core 2方法以支持神经科学PI，并跟踪Core 2活动并向NIH社区传播/共享资源。新实施的应用将包括用于高分辨率代谢成像和射频诱导热沉积测量的各种多核MRS方法。核心2的总体目标是加强NINDS和NIH资助的研究。

MRS in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. However the application of MRS by neuroscientists is hindered by a steep learning curve as well as technological barriers, which include the need for significant resource and expertise centralization. In the last cycle. Core 2 implemented and provided support for the use of a wide range of state-of-the-art MRS methods and combined studies of MRS with MRI (Core 1) and neurophysiological recordings (Core 3) in conjunction with project-specific data analysis (Core 4). Through new user recruitment as well as support and training. Core 2 now supports the work of 7 qualifying Pis funded by NINDS who along with 16 other NIH-funded Pis use multinuclear MRS to address fundamental questions in basic and clinical neuroscience. The impact of Core 2 is further shown by support of work in 26 NIH grants and 3 new research initiatives that led to ROI grants, training of 5 neuroscientists in the use of MRS methods, and contributing to 50 papers that led to 604 citations (for Core 2 alone this represents 50% of the total citations for 106 papers for al| Cores). For the next cycle, we will continue to implement, maintain, and support innovative multinuclear MRS methods for Core 2 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their staff for Core 2 usage, integrate synergistic use of MR/neurophysiological measurements and project-specific data analysis, implement new Core 2 methods to support neuroscience Pis, and track Core 2 activities and disseminate/share resources to NIH community. The newly implemented applications will include a variety of multinuclear MRS methods for high-resolution metabolic imaging and RF induced heat deposition measurements. The overall goal of Core 2 is to enhance NINDS- and NIH-funded research.