Oral Health in Breast Cancer Survivors on Aromatase Inhibitors

说明(申请人提供)：芳香酶抑制剂(AIs)是激素受体阳性乳腺癌绝经后妇女的常规激素辅助治疗药物。芳香酶抑制与其严重的雌二醇(雌激素)消耗有关，与低骨密度和骨质疏松症风险增加以及骨折风险增加有关。AIS及其导致的激素消融对乳腺癌女性口腔健康和口腔健康相关生活质量的潜在影响尚不明确。密歇根大学将在多学科环境中开展一个项目。一项横断面研究将用于评估150名有早期乳腺癌病史的绝经后妇女接受辅助人工智能治疗的口腔症状患病率，以及150名从密歇根大学卫生系统招募的绝经后非癌症妇女的口腔症状患病率。全面的口腔检查(包括评估粘膜病变、牙周检查、龋齿、口腔X光检查、口腔液体检查和牙齿脱落检查)。将向所有参与者发放评估社会人口和行为因素以及生活质量信息的问卷。将酌情使用Logistic回归模型来分析关联的优势。这项提议为琳达·苏珊·泰希曼博士在口腔健康领域的职业发展提供了一个全面的计划，因为它与辅助治疗和乳腺癌生存有关。短期目标是在以患者为中心的研究中获得临床研究方面的技能，并获得与内分泌治疗和口腔健康的独立研究所必需的辅助性芳香酶抑制剂相关的口服效应的知识。长期目标是通过开发旨在改善乳腺癌幸存者的健康和保健的循证医生指南战略，加强医学教育和牙科之间的联系。教学培训和有指导的研究活动将为泰希曼博士提供基础，她可以在该奖项的最后几年提交竞争激烈的拨款申请，并开发未来的研究，以了解乳腺癌幸存者的最佳口腔护理。这项拟议的研究与NIDCR的使命中与发展与癌症治疗的口腔健康相关的基础知识有关的部分有关。最终，这些信息可能会提高牙科健康专业人员和肿瘤学家预测和减轻人工智能治疗的口服毒性的能力。

DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) are routinely prescribed as adjuvant hormonal therapy for postmenopausal women with hormone receptor positive breast cancer. Aromatase inhibition with its profound estradiol (estrogen) depletion, is associated with an increased risk of low bone mineral density and osteoporosis with increased fracture risk. The potential impact of AIs and their resulting hormone ablation on oral health and oral health related quality of life in women with breast cancer is undefined. A project will be conducted at University of Michigan in a multidisciplinary environment. A cross-sectional study will be used to assess the prevalence of oral symptoms among 150 post-menopausal women with a history of early stage breast cancer receiving adjuvant AI therapy and 150 postmenopausal women without cancer recruited from the University of Michigan Health System in Southeastern Michigan. Comprehensive oral examinations (including assessment of mucosal lesions, periodontal measures, dental caries, oral x-rays, oral fluid, and tooth loss examination will be performed). Questionnaires assessing socio-demographic and behavioral factors as well as quality of life information will be administered to all participants. Logistic regression modeling will be used to analyze the strengths of associations as appropriate. This proposal provides a comprehensive plan for the career development of Dr. Linda Susan Taichman in the area of oral health as it pertains to adjuvant therapy and breast cancer survivorship. Short-term goals are to acquire skills in clinical research expertise in patient centered studies and to gain knowledge of adjuvant aromatase inhibitor related oral effects necessary for independent investigations of endocrine therapies and oral health. Long-term goals are to strengthen the linkage between Medical education and Dentistry by developing evidence-based physician guideline strategies aimed at improving the health and healthcare of breast cancer survivors. The didactic training and mentored research activities will provide Dr. Taichman with the foundation from which she can submit highly competitive grant applications in the final years of the award and develop future studies to understand optimal oral care for breast cancer survivors. The proposed research is relevant to that part of NIDCR's mission that pertains to developing fundamental knowledge concerning oral health related effects of cancer therapies. Ultimately, this information may improve the dental health professional's and the oncologist's ability to anticipate and mitigate oral toxicities from AI therapy.