Nutrition Education for Cardiovascular Disease Prevention in Individuals with Spi

描述（由申请人提供）：该K奖的目标是提供发展支持，使杰西·利伯曼博士成为慢性脊髓损伤（SCI）患者心血管疾病（CVD）预防领域的独立研究者。慢性脊髓损伤患者的心血管疾病风险因素，如血脂异常、糖尿病和中心性肥胖，与匹配的健全对照相比，发病率更高。因此，与一般人群相比，心血管疾病在这一人群中更为普遍和过早发生。这项研究的题目是“脊髓损伤患者预防心血管疾病的营养教育：一项随机对照试验”。目的探讨急性康复期附加营养教育对营养知识的影响。

DESCRIPTION (provided by applicant): The goal of this K Award is to provide developmental support that will allow Dr. Jesse Lieberman to become an independent investigator in the area of cardiovascular disease (CVD) prevention for individuals with chronic spinal cord injury (SCI). Individuals with chronic SCI are known to have an increased prevalence of CVD risk factors such as dyslipidemia, diabetes, and central obesity compared to matched, able-bodied controls. Subsequently, CVD is more prevalent and occurs prematurely in this population compared to the general population. The study is entitled "Nutrition education for cardiovascular disease prevention in individuals with spinal cord injury: A randomized controlled trial." The purpose is t investigate the effect of additional nutrition education during acute rehab on nutrition knowledge, diet quality, weight status, and metabolic CVD risk over the course of one year among persons with acute SCI. This proposal is highly innovative because additional nutrition education has not been studied during acute rehab, and very little CVD prevention research has been conducted in the SCI population. This study has public health significance because there are approximately 12,000 traumatic SCI/year along with several thousand non-traumatic SCI/year and an estimated 1,275,000 Americans living with a SCI, and because of the increased prevalence of CVD, obesity and diabetes in the SCI population compared to the general population. The proposed research experiences and the associated career development plan will provide Dr. Lieberman with training in multidisciplinary research that is essential to address a complex problem such as CVD in the chronic SCI population. The career development aspect of this award includes: strong, multidisciplinary mentorship; graduate courses in nutrition, grant writing, and ethics; attending national conferences and workshops; mentored nutrition research experience; nutrition journal article reviews; and a leadership course. The candidate is well qualified to benefit from the proposed career development plan. He has demonstrated a significant commitment to a research career and substantial productivity through work supported by an NHLBI Research Supplement to Promote Diversity in Health Related Research, and other studies funded by his institution and other sources. He will work closely with his mentors and advisory committee during the five years of the proposed award to achieve the competencies needed to become an independent investigator supported by R01 funding and/or VA merit review. At least 75% of the applicant's time will be fully committed and dedicated to the research and career development plan in this proposal. The significance of this proposal relates to the large size of the SCI population, the considerable burden of CVD in this population, and the potential for prevention through nutritional lifestyle behavior change. The results of this researc have the potential to make a significant positive effect on the care and outcomes of individuals with SCI. Furthermore, the research competencies developed will enable Dr. Lieberman to make substantial impact through future research endeavors. (End of Abstract)