Implementation of an Elementary and Robust Implantable Sensor for Musculoskeletal

描述（由申请人提供）：智能植入物在促进肌肉骨骼疾病个性化医疗方面的临床应用是巨大的。在患者特异性的基础上，植入物的物理环境提供了大量关于愈合进展和预后的诊断数据。通过个性化医疗的定制护理，通过促进对个体患者的更好诊断和最佳治疗方案，降低了成本并改善了结果。以前用于研究的智能植入系统由于复杂性、成本和需要的修改而不能适应日常临床实践

DESCRIPTION (provided by applicant): The clinical utility of smart implants to facilitate personalized medicine in musculoskeletal disease is vast. On a patient-specific basis, the implant's physical environment provides a wealth of diagnostic data regarding the progression of healing and prognosis of an outcome. Customized care through personalized medicine reduces costs and improves outcomes by facilitating better diagnoses and optimal treatment regimens for individual patients. Previous smart implant systems used for research have not been adaptable to daily clinical practice due to complexity, cost, and the required modification of host implants. In this project, we will develop and implement a simple, robust, inexpensive, battery-less, telemetry-less, single component implantable sensor with no electrical connections for musculoskeletal smart implants. We will demonstrate that the sensor meets the criteria to facilitate personalized musculoskeletal medicine in daily clinical practice. The sensors will be integrated into spinal implants to (a) objectively correlate in vivo force to progress of spinal fusion, and (b) quantify real time in vivo multi-axial interbody force (axial and shear) during dynamic activities in the goat cervical spine.