Affective and Neurocognitive Dimensions across Eating Disorder Psychopathology

描述(由申请者提供)：本申请是一项以患者为导向的研究职业发展奖，旨在为应聘者提供一个成功的职业生涯基础，成为一名独立的调查员，在神经认知和负性情感方面的生物行为研究方面具有专业知识，这些都是进食障碍精神病理学的基础。该应用程序的培训和研究目标与NIMH战略计划的策略1.4一致，以开发基于行为和神经生物学维度的研究的精神病理学分类的新方法。候选人寻求在三个领域进行高级培训：(1)研究和分类精神病理学的维度和多方法方法，(2)神经认知和相关任务，(3)神经生物学和使用功能磁共振成像(FMRI)从理论上研究进食障碍中相关的神经回路。培训将由一个由导师和顾问组成的跨学科小组提供指导，并将涉及整个供资期间的正式活动(如课程作业、讲习班)和非正式活动(如定向阅读、辅导会议)。该研究计划提出了两项研究，以阐明神经认知和情感变量在进食障碍精神病理学中的作用。在第一项研究中，将从社区和临床环境中招募80名患有一系列临床上有意义的进食障碍精神病的妇女，对神经认知(例如，反应抑制、决策)和消极情感(例如，情绪反应、痛苦耐受性)的维度进行检查。参与者将完成半结构化访谈、自我报告测量和行为任务，以检查神经认知和情感维度与进食障碍精神病理学的认知和行为表现之间的关联程度。在第二项研究中，一个由24名参与者组成的样本将完成一项功能磁共振成像方案，该方案将评估与反应抑制和负面情感刺激处理相关的静息状态活动和任务诱发活动，这些参与者包括患有临床显著进食障碍精神病理学的女性(n=12)和非进食障碍对照组(n=12)。这项研究将提供以暴饮暴食为特征的进食障碍表现中与抑制控制和情感功能相关的神经回路的数据。重要的是，这些结果可能有助于改进现有的进食障碍治疗方法，并开发针对正在调查的生物行为变量的新干预措施。总之，本申请中提出的高级培训目标和研究将有助于候选人成功地成为以患者为导向的研究的独立调查者，拥有饮食失调领域的特殊专业知识，以及与进食障碍精神病理学潜在的生物行为功能维度研究的新计划相一致的相关方法和统计方法。

DESCRIPTION (provided by applicant): This application for a Mentored Patient-Oriented Research Career Development Award proposes training and research designed to provide the candidate with a foundation to establish a successful career as an independent investigator with expertise in biobehavioral research on dimensions of neurocognition and negative affectivity that underlie eating disorder psychopathology. The training and research goals of this application are consistent with Strategy 1.4 of the NIMH Strategic Plan to develop new ways of classifying psychopathology for research based on behavioral and neurobiological dimensions. The candidate seeks advanced training in three areas: (1) dimensional and multi-method approaches to studying and classifying psychopathology, (2) neurocognition and associated tasks, and (3) neurobiology and the use of functional magnetic resonance imaging (fMRI) to study theoretically relevant neurocircuitry in eating disorders. Training will be guided by an interdisciplinary team of mentors and consultants and will involve formal (e.g., coursework, workshops) and informal (e.g., directed readings, mentoring meetings) activities across the funding period. The research plan proposes two studies to elucidate the role of neurocognitive and affective variables in eating disorder psychopathology. In the first study, dimensions of neurocognition (e.g., response inhibition, decision making) and negative affectivity (e.g., emotional reactivity, distress tolerance) will be examined in a broad sample of 80 women recruited from community and clinical settings who present with a range of clinically significant forms of eating disorder psychopathology. Participants will complete semi-structured interviews, self-report measures, and behavioral tasks to examine the extent to which the neurocognitive and affective dimensions are associated with cognitive and behavioral manifestations of eating disorder psychopathology. In the second study, a sample of 24 participants comprised of women with clinically significant eating disorder psychopathology involving binge eating (n=12) and non-eating disorder controls (n=12) will complete an fMRI protocol assessing resting-state activity and task-evoked activity associated with response inhibition and processing of negative affective stimuli. This study will provide data on neurocircuitry associated with inhibitory contro and affective functioning in eating disorder presentations characterized by binge eating. Importantly, these results may inform efforts to refine existing eating disorder treatments and develop new interventions targeting the biobehavioral variables under investigation. In sum, the advanced training goals and research proposed in this application will facilitate the candidate's success in becoming an independent investigator in patient-oriented research, with particular expertise in the field of eating disorders, as well as associated methodological and statistical approaches consistent with a novel program of research on dimensions of biobehavioral functioning underlying eating disorder psychopathology.