Ripple Effect of Lifestyle Intervention During Pregnancy on Partners' Weight

描述（由申请人提供）：针对超重个体的生活方式干预可以对家中未经治疗的超重伴侣产生积极的“连锁反应”。有趣的是，当干预措施针对女性时，对伴侣体重的连锁反应最为明显。妇女，特别是母亲，仍然是家中主要的“营养看门人”。尽管人们普遍认为母性是行为改变的强大动力，但迄今为止还没有研究调查针对母亲妊娠期体重增加的产前生活方式干预的“连锁反应”。本研究的主要目的是确定生活方式干预是否会对家中未接受治疗的伴侣产生积极的“连锁反应”，以防止超重/肥胖孕妇孕期体重过度增加。拟议的研究是LIFE-moms联盟的两项随机III期临床试验的辅助研究（1U01HL114377-01, PI Phelan; 3U01DK094418-01S1， PI Martin和Redman），这两项试验正在检查多组分生活方式干预对防止650名超重/肥胖妇女妊娠期体重过度增加的疗效。在这项辅助研究中，研究人员将评估怀孕伴侣在妊娠13周（研究开始）、妊娠35周以及产后6个月和12个月时的体重、家庭环境和心理社会行为。我们假设，随机选择生活方式干预的孕妇的伴侣，相对于标准治疗，将有更大的体重减轻

DESCRIPTION (provided by applicant): Lifestyle interventions targeting overweight individuals can produce positive "ripple" effects on untreated overweight partners in the home. Interestingly, ripple effects on partners' weight appear most pronounced when the interventions target women. Women, and mothers in particular, remain the primary "nutritional gatekeepers" of the home. Despite widespread recognition that motherhood is a powerful motivator for behavior changes, no study to date has examined the "ripple" effects of prenatal lifestyle interventions that target mothers' gestational weight gain. The primary aim of the proposed study is to determine whether lifestyle interventions to prevent excessive gestational weight gain in overweight/obese pregnant women have positive "ripple" effects on untreated partners in the home. The proposed study is ancillary to two randomized phase III clinical trials in the LIFE-moms consortium (1U01HL114377-01, PI Phelan; 3U01DK094418-01S1, PIs Martin and Redman) that are examining the efficacy of multi-component lifestyle interventions to prevent excessive gestational weight gain in a total of 650 overweight/obese women. In this ancillary study, partners' weight, home environment, and psychosocial behaviors will be assessed when their pregnant partners are ~13 weeks gestation (study entry), 35 weeks gestation and at 6 and 12 months postpartum. We hypothesize that partners of pregnant women randomized to the lifestyle intervention, relative to those of standard care, will have greater weight losses through 12-months. Secondary aims examine partner improvements in weight control behaviors, the home environment, and psychosocial parameters. This project is highly innovative, as it capitalizes on existing funded research and is the first study to examine ripple effects of multicomponent prenatal interventions. The project also has high impact, as pregnancy is a powerful motivator for behavior and environmental changes in the home; and, if positive ripple effects occur, the field of obesity treatment and prevention could move beyond focus on individual level to the often unrecognized interpersonal effects of lifestyle interventions.