Shared Resource Group 2: Preclinical and Clincal Science

分子临床试验共享资源（MCTSR）是一个高度专业化的资源，为前瞻性临床试验中药物靶点和药物活性的分子测定提供专家建议和技术及实验支持。MCTSR收集、处理和分析 来自在分子靶向治疗的前瞻性临床试验中接受治疗的患者的样本。资源支持贯穿整个研究过程，从最初的研究设计和规划到结果的实施和解释。MCTSR目前正在支持SJCCC和合作团体内的17项临床试验，并正在参与所有四个治疗患者的SJCCC项目。在本报告所述期间，该资源为报告七个I期的论文提供了分子生物学服务。 临床试验和5项II期研究，其中7项发表在《临床肿瘤学杂志》上。 该资源为另外9篇论文提供了主要的分子生物学服务，包括发表在Nature，Nature Medicine和Cancer Cell上的研究。

The Molecular Clinical Trials Shared Resource (MCTSR) is a highly-specialized resource that provides expert advice and technological and experimental support for the conduct of molecular assays of drug targets and drug activity within prospective clinical trials. The MCTSR, collects, processes and analyzes samples from patients treated within prospective clinical trials of molecular targeted therapies. Resource support extends throughout the entire research process from initial study design and planning through to the implementation and interpretation of results. The MCTSR is currently supporting 17 clinical trials within the SJCCC and cooperative groups and is engaging all four SJCCC programs that treat patients. During the current reporting period the resource provided molecular biology services to papers reporting seven Phase I clinical trials and five Phase II studies, of which seven were published in the Journal of Clinical Oncology. The resource contributed major molecular biology services to a further nine papers, including studies published in Nature, Nature Medicine, and Cancer Cell.