Imaging, Methodology and Statistics Core

项目总结(见说明)： IMS核心将继续协调神经成像和非神经成像测量的有效和一致的利用，并为该计划项目赠款(PPG)提供跨项目和核心的统计支持。IMS核心提供了便于调查人员访问的方法和人员支持，是图像数据采集、处理、分析和评估的技术核心。核心还提供数据管理支持，是每个项目的组成部分，并与所有项目和核心挂钩。IMS核心还将继续：1)为PET和MR数据采集提供有效和标准化的神经成像方法，并及时进行分析和评估；2)提供数据管理，确保及时和安全地输入、存储、检索、质量控制(QC)检查和存档；3)提供统计咨询；4)作为方法学培训资源。PPG更新期的IMS核心目标是：目标1.获取和管理用于评估淀粉样蛋白沉积和代谢率(通过PET)和组织体积、形态计量学差异、白质损伤、和血流(通过核磁共振)目标2.为主要(和探索性)目标提供可靠的结构和功能神经成像测量目标3.提供可用于确定神经成像测量随时间和相对于非成像协变量和/或死后相关性的时间和空间特征的工具目标4.为研究人员提供成像和统计咨询以实现项目目标5.为学生和教职员工提供淀粉样成像和相关神经成像方法方面的培训

PROJECT SUMMARY (See instructions): The IMS Core will continue to coordinate efficient and consistent utilization of neuroimaging and nonneuroimaging measures and provide statistical support across projects and cores for this program project grant (PPG). The IMS Core provides methods and staff support that is readily accessible to investigators and is a technical core for image data acquisition, processing, analysis, and evaluation. The Core also provides data management support and is an integral component of each project and is linked to all projects and Cores. The IMS core will also continue to: 1) provide valid and standardized neuroimaging methods for PET and MR data acquisition with timely analysis and evaluation; 2) provide data management that ensures timely and secure data entry, storage, retrieval, quality control (QC) checks, and archiving; 3) provide statistical consultation; and 4) serve as a methodology training resource. The IMS Core aims for the PPG renewal period are: Aim 1. To acquire and manage neuroimaging data used to assess amyloid deposition and metabolic rate (via PET) and tissue volume, morphometric differences, white matter lesions, and blood flow (via MRI) Aim 2. To provide robust structural and functional neuroimaging measures for primary (and exploratory) aims Aim 3. To provide tools that can be used to determine temporal and spatial characteristics of neuroimaging measures across time and relative to non-imaging covariates and/or post-mortem correlates Aim 4. To provide imaging and statistical consultation to investigators to achieve the project aims Aim 5. To provide training to students and faculty in amyloid imaging and related neuroimaging methodology.