Acquisition of an X-Rad 320 Biological Irradiator

描述（由申请人提供）：我们正在申请精密X-Rad 320生物辐照器的资金。该仪器将提供450kB高稳定性，高频x射线，提供高度可重复性和相干的辐射场。纽纽尔大学医学中心有许多研究项目依赖于向屏障动物体内的实验性啮齿动物提供受控辐射的能力。由于飓风“桑迪”的影响，斯迈洛中央动物饲养场的辐射器被摧毁。该展览馆正在亚历山大中心西塔进行重建。动物辐照器的可用性对于正在进行的关于在该动物园内饲养的动物的项目至关重要。所要求的仪器的一个主要优点是它依赖于x射线管作为辐射源，而不是更传统的含有放射性铯或钴的同位素辐射源。因此，X-Rad 320缺乏维护放射性同位素辐照器所固有的主要国土安全问题，大大简化了安装、使用和监督。Precision X-Rad 320将被放置在西塔Vivarium的共享程序空间内，供主要用户组的实验室工作人员以及辅助的次要用户使用。该单位将在科学和研究办公室实验室资源司的监督下。它将由此应用程序的PI， Assoc直接管理。大卫·列维院长和他的行政人员在合作科学办公室。主要和次要用户群来自众多学术部门，代表了基础和转化研究领域，如癌症、免疫学、传染病、心脏病学、炎症和DNA修复。NIH资助的用户加起来将使用仪器容量的75%。剩余的仪器容量将通过在线调度程序提供给任何在动物园内饲养动物的研究人员。这些调查人员将主要是新招募的初级教员，他们正在收集数据，以支持他们向NIH提交的首次报告。该仪器在核心环境中的可用性将使所有用户，包括获得NIH资助和动物辐照研究需求的未来用户，都可以充分使用该仪器。虽然校园里还有其他动物辐照器，但由于对隔离条件下饲养的动物进行研究的特殊需要，要求每个隔离动物舍都有自己的辐照器。因此，在西塔Vivarium内，没有任何专用的散热器可以替代。

DESCRIPTION (provided by applicant): We are requesting funds for a Precision X-Rad 320 Biological Irradiator. This instrument will provide 450kB high stability, high frequency x-rays, providing a highly reproducible and coherent irradiation field. There are numerous research projects at NYULMC that rely on the ability to deliver controlled irradiation to experimental rodents housed within the barrier vivarium. Due to Hurricane Sandy, the irradiator in the Smilow Central Animal Vivarium was destroyed. The vivarium is being reconstructed in the West Tower of the Alexandria Center. Availability of an animal irradiator is vital for ongoing projects on animals to be housed in this vivarium. A major advantage of the requested instrument is its reliance on an x-ray tube as a radiation source, rather that the more traditional isotope irradiators that contain radioactive cesium or cobalt. Thus, the X-Rad 320 lacks the major Homeland Security concerns inherent in maintaining a radioisotope-based irradiator, greatly simplifying installation, use, and oversight. The Precision X-Rad 320 will be placed within a shared procedure space within the West Tower Vivarium, where is will be available for use by the laboratory staff of the major user group, as well as ancillary minor users. The unit will be under the oversight of the Division of Laboratory Resources of the Office of Science and Research. It will be directly administered by the PI of this application, Assoc. Dean David Levy and his administrative staff in the Office of Collaborative Science. The major and minor user group comes from numerous academic departments and represents both basic and translational research areas, such as, cancer, immunology, infectious diseases, cardiology, inflammation, and DNA repair. The NIH funded users combined will use 75% of the instrument capacity. Remaining instrument capacity will be made available to any researcher with animals housed in the vivarium through an on-line scheduler. These investigators will be largely newly-recruited junior faculty who are gathering data in support of their first submissions to NIH. The availability of this instrument in a Core setting will make it fully available to all users, includng future users as they acquire NIH funding and research needs of animal irradiation. Although there are other animal irradiators on campus, the special needs of research on animals housed under barrier conditions require that each barrier vivarium have its own irradiator. Therefore, there is no substitute for a dedicated irradiator such as this within the West Tower Vivarium.