Training Program in Molecular Oncology and Immunology

描述（由申请人提供）：本提案请求资金继续支持我们在分子肿瘤学和免疫学方面的综合培训项目。我们要求支持培养5名分子肿瘤学和免疫学综合学科的博士生和10名博士后（博士，医学博士或医学博士/博士）。培训侧重于这一跨学科领域的综合教育，使学员更好地了解细胞转化、生长控制、肿瘤发生和进展以及免疫反应的调控机制。该计划的一个特别重点是改进癌症诊断和治疗的转化方法。这些学科的交叉融合使得研究原癌基因和免疫相关细胞和组织在正常状态和肿瘤情况下的全新方法得以发展，促进了癌症转化研究的发展。该计划的独特之处在于，学员将熟练掌握免疫学和分子肿瘤学的基础知识；学生们将在临床环境中接触到大量的癌症研究；学生有机会深入研究癌症相关项目；学员将熟练掌握当前文献的批判性评价、实验数据的分析和研究结果的展示；所有受训者都接受了负责任的研究行为教育。来自病理学、细胞生物学、生物化学、药理学、医学、儿科、泌尿外科、放射肿瘤学、皮肤病学、放射学和微生物学等部门的39名教员作为主要导师参与该项目，并辅以一组坚定的临床教育工作者作为副教员。该项目在萨克勒基础医学研究所和纽约大学癌症研究所的支持下，充分利用纽约大学医学院广泛的基础和临床癌症研究基础设施，使学员密切参与尖端癌症研究的实践和智力严谨。

DESCRIPTION (provided by applicant): This proposal requests funds for continued support of our comprehensive training program in molecular oncology and immunology. We request support to training 5 predoctoral and 10 postdoctoral fellows (PhD, MD or MD/PhD) in the integrated discipline of molecular oncology and immunology. Training focuses a combined education in this interdisciplinary area, to provide trainees with a better understanding of the regulatory mechanisms involved in cellular transformation, growth control, tumor initiation and progression, and immunological responses. A particular focus of the program is on translational approaches to improved cancer diagnosis and treatment. Cross-fertilization of these disciplines allows development of entirely new approaches to study both proto-oncogenes and immunologically relevant cells and tissues in their normal state as well as in neoplastic situations, fostering the development of translational research in cancer. The unique aspects of this program are that trainees become proficient in the basics of both immunology and molecular oncology; the students receive a significant exposure to cancer research in a clinical setting; the students have the opportunity for in-depth research on a cancer related project; the trainees become proficient in critical evaluation of the current literature, analysis of experimental data, and presentation of the results of research; and all trainees are educated in the responsible conduct of research. Thirty-nine faculty members from the Departments of Pathology, Cell Biology, Biochemistry, Pharmacology, Medicine, Pediatrics, Urology, Radiation Oncology, Dermatology, Radiology and Microbiology participate as primary mentors in this program, and they are supplemented with a committed set of clinician-educators as Associate Faculty. The program is under the aegis of the Sackler Institute for Basic Medical Sciences and the New York University Cancer Institute and makes full use of the extensive basic and clinical cancer research infrastructure of New York University School of Medicine to intimately involve trainees in both the practical and the intellectual rigors of cutting-edge cancer research.