NCIC Clinical Trials Group - Canadian Collaborating Clinical Trials Network

描述(由申请人提供)：NCTN计划的总体目标是“在广泛的疾病和不同的患者群体中进行决定性的、随机的、晚期的临床治疗试验和高级成像试验，以及这些试验的初步开发工作，作为NCI针对成人和儿童癌症患者的整体临床研究计划的一部分。”NCIC CTG的使命是“开发和进行临床试验，旨在改善癌症的治疗和预防，最终目标是减少这种疾病的发病率和死亡率。”这些目标的重叠为加拿大合作临床试验网络创造了理由。加拿大人和美国人对改善健康结果的相似社会期望以及NCIC CTG和NCTN各自相似的战略优先事项进一步支持了这一理论，它们认识到对致癌分子基础的新理解有可能促进医疗保健的提供，包括通过改进针对癌细胞的治疗靶向和更好地确定针对个别患者的治疗方法。NCIC CTG的具体目标是通过其新成立的国家临床试验网络计划，与NCI/CTEP和美国的小组合作，在NCIC CTG的领导下开发新的组间试验，确保更快地产生由美国小组领导的试验，通过评估更多的终点来提高这些试验的科学含量，并促进对临床试验方法学和分析的新理解。这一目标得益于NCIC CTG独特的信息技术支持和对加拿大监管环境的了解。这项申请的目的是促进加拿大领导从美国联邦资金支出的角度代表价值的NCTN试验，并在加拿大进行美国领导的NCTN试验。

DESCRIPTION (provided by applicant): The overall goal of the NCTN Program is to "conduct definitive, randomized, late phase clinical treatment trials and advanced imaging trials across a broad range of diseases and diverse patient populations, as well as development efforts preliminary to those trials, as part of the NCI's overall clinical research program for adults and children with cancer." The mission of the NCIC CTG is "to develop and conduct clinical trials aimed at improving the treatment and prevention of cancer with the ultimate goal of reducing morbidity and mortality from this disease." The overlaps of these goals create a rationale for a Canadian Collaborating Clinical Trials Network. This rationale is further supported by similar societal expectations by Canadians and Americans for improved health outcomes and similar respective strategic priorities of NCIC CTG and the NCTN that recognize that new understandings of the molecular basis of carcinogenesis have the potential to advance health care delivery, including through improved therapeutic targeting of the cancer cell and better identification of therapies for individual patients. The specific objectives of NCIC CTG to collaborate with NCI/CTEP and US-based groups, through its newly-formed National Clinical Trials Network Program, to develop new Intergroup trials under NCIC CTG leadership and to ensure more rapid accrual to trials led by US-based groups, to enhance the scientific content of these trials through evaluation of additional endpoints and to contribute to new understandings of clinical trial methodology and analysis. This aim is facilitated by NCIC CTG's unique information technology supports and understandings of the Canadian regulatory environment. The aims of this application are to facilitate Canadian leadership of NCTN trials that represent value from the perspective of expenditure of U.S. federal dollars and to conduct U.S.-led NCTN trials in Canada.