Beagle-2

描述：生物医学研究越来越依赖于大数据分析和大规模模拟。2009年，芝加哥大学生物科学部将计算生物医学确定为其研究、招聘和战略投资的主要战略重点。这项计划的核心是收购Beagle-1，这是一台18,000核、600 TB的超级计算机，是世界上致力于生物和医学研究的最强大的机器之一。自2011年初首次亮相以来，来自89个项目的300多名研究人员使用了Beagle-1，利用了超过3亿核心小时的计算时间。有了Beagle-1，科学家们推动了癌症、神经科学、遗传学、心血管疾病、微生物学、药物设计和其他领域的研究前沿。在Beagle-1上进行的工作还促使芝加哥大学校园和整个芝加哥地区出现了一个充满活力的计算生物医学社区，教职员工、博士后、学生和工作人员从频繁的研讨会、研讨会和教育机会中受益。随着Beagle-1生命接近尾声，对生物医学超级计算的需求激增，需要购买一种新的、更强大的资源：Beagle-2，这是一款23,808核、1.3 PB的Cray XE6系统。这一重大升级将使计算和大数据存储能力增加两倍，同时还将为研究人员提供到2017年的服务。据估计，该系统每年1.5亿个核心工作时间已经可以被NIH资助的活跃项目所填补，这些项目研究癌症和肌病的遗传学、人类肠道的微生物学及其与疾病的关系、使用医学图像来创建癌症的个性化治疗、阿尔茨海默病的细胞生物学、大脑语言中心的进化起源等。Beagle-2将允许芝加哥大学进一步开发生物医学计算设施，以加强研究和患者护理，培养下一代生物医学计算专家，使芝加哥地区和其他地区的研究人员能够进行合作，并产生革命性的新方法、软件工具和数据产品，将在全球范围内推进生物医学研究。

DESCRIPTION: Biomedical research increasingly depends on big data analysis and large-scale simulation. In 2009, the University of Chicago's Biological Sciences Division identified computational biomedicine as its major strategic focus for research, recruitment and strategic investment. The centerpiece of this initiative was the acquisition of Beagle-1, an 18,000-core, 600 TB supercomputer that ranked among the world's most powerful machines dedicated to biological and medical research. Since its debut in early 2011, more than 300 researchers from 89 projects have used Beagle-1, utilizing over 300 million core-hours of computing time. With Beagle-1, scientists pushed forward the frontiers of research on cancer, neuroscience, genetics, cardiovascular disease, microbiology, drug design, and other areas. Work conducted on Beagle-1 also sparked the emergence of a vibrant computational biomedicine community on the University Chicago campus and across the Chicago region, where faculty, post-docs, students and staff benefit from frequent workshops, seminars and educational opportunities. The surge in demand for biomedical supercomputing concomitant with Beagle-1 approaching the end of its life necessitates the acquisition of a new, more powerful resource: Beagle-2, a 23,808-core, 1.3 petabyte Cray XE6 system. This major upgrade will increase computational and big data storage capabilities by two fold while also delivering service for researchers through 2017. An estimated 150 million core hours per year for this system can already be filled by active, NIH-funded projects studying the genetics of cancer and myopathies, the microbiology of the human gut and its relationship to disease, the use of medical images to create personalized treatments for cancer, the cell biology of Alzheimer's disease, the evolutionary origins of language centers in the brain, and much more. Beagle-2 will allow the University of Chicago to further develop a biomedical computing facility that enhances research and patient care, trains the next generation of biomedical computing experts, enables collaboration by researchers across the Chicago region and beyond, and produces transformative new methods, software tools, and data products that will advance biomedical research on a global scale.