Building protected data sharing networks to advance cancer risk assessment and treatment

项目摘要 基因组学和数据分析的进步为准确的风险预测和 通过跨机构的大规模数据联合，对即使是罕见的癌症进行个性化医疗。还没有 癌症研究经常因为缺乏适当的工具来简化临床数据的传输和共享而受到阻碍 用于癌症研究的患者数据。Globus服务允许安全地传输、同步和共享 大规模的分布式环境。我们建议在这里扩展这些服务，以便它们适合 安全地使用受保护的人类数据。扩展的服务将允许联合临床患者数据 用于准确的癌症风险预测、个性化治疗以及任何其他癌症研究领域。 Globus被广泛使用，有超过15,000个用户，超过8,000个存储系统可通过Globus访问， 包括大多数美国顶尖大学和许多海外网站，以及超过165PB和250亿 已传输的文件。生物医学研究人员采用Globus的速度很快，而且还在加速。生物医学 来自大约30所大学、政府机构和测序中心的研究人员依赖于Globus 简化了数据传输和共享。我们的“Globus基因组学”(GG)集成了银河-Globus-Cloud基因组学 分析系统已被多个生物医学研究领域的300多名研究人员使用， 包括癌症在内，在超过25个机构分析了超过10,000个样本。 我们将开发HIPAA Enablement工具包，支持Globus和其他软件即服务提供商 (包括GG)安全地管理受保护的数据(目标1.1)。我们将通过以下方式扩展Globus安全功能 实现文件名加密，并使用用户提供的密钥加密数据，并演示这些 GG和其他服务可以使用新功能来实现弹性、安全、高性能的癌症 基因组数据分析(AIM 1.2)。我们将通过开发统一的云平台，将Globus与主要的云平台集成 存储系统接口(Aim 2.1)，设计高速传输(Aim 2.2)，以及实现搜索， 基于AWS、Google、Microsoft和OpenStack的云上的复制和同步(AIM 2.3)，因此 癌症研究人员可以在这些和其他(例如，本地)之间安全、轻松地传输和共享数据 计算和存储平台。生成的工具将适用于癌症中的任何癌症类型 研究光谱。我们将首先在现有的和新兴的领域内验证和传播这些新技术 乳腺癌(目标3.1)、血液(目标3.2)和胰腺(目标3.3)癌症研究网络，然后更广泛 与癌症研究连续体的合作者(目标3.4)。我们将与合作者密切合作， 以确保我们满足广泛的癌症研究社区的需求 需要传输、共享和分析大型人工数据集。我们将利用广泛的社区推广活动 通过多渠道广泛传播我们的技术。

Project Summary Advances in genomics and data analytics create new opportunities for accurate risk prediction and personalized medical treatment for even rare cancers via large-scale data federation across institutions. Yet cancer research is often stymied by a lack of appropriate tools to streamline the transfer and sharing of clinical patient data for cancer research. Globus services permit secure data transfer, synchronization, and sharing in distributed environments at large scale. We propose here to extend these services so that they are appropriate to work securely with protected human data. The extended services will allow federation of clinical patient data for accurate cancer risk prediction, personalized treatment, as well as any other cancer research area. Globus is widely used, with over 15,000 users, more than 8,000 storage systems accessible via Globus, including at most leading US universities and many sites overseas, and more than 165 petabytes and 25 billion files transferred. Adoption of Globus by biomedical researchers has been rapid and is accelerating. Biomedical researchers at ~30 universities, government agencies, and sequencing centers have relied on Globus for streamlined data transfer and sharing. Our “Globus Genomics” (GG) integrated Galaxy-Globus-cloud genomics analysis system has been used by more than 300 researchers across multiple biomedical research domains, including cancer, at over 25 institutions to analyze over 10,000 samples. We will develop a HIPAA Enablement Toolkit that will enable Globus and other software-as-a-service providers (including GG) to manage protected data securely (Aim 1.1). We will extend Globus security features by implementing file name encryption and by encrypting data with user-supplied keys, and demonstrate that these new features can be used by GG and other services to enable elastic, secure, high-performance cancer genomics data analysis (Aim 1.2). We will integrate Globus with major cloud platforms by developing uniform storage system interfaces (Aim 2.1), engineering high-speed transfers (Aim 2.2), and implementing search, replication, and synchronization (Aim 2.3) on AWS, Google, Microsoft, and OpenStack-based clouds, so that cancer researchers can transfer and share data securely and easily among these and other (e.g., local) computing and storage platforms. The resulting tools will be applicable to any cancer type across the cancer research spectrum. We will validate and disseminate these new technologies first within existing and emerging breast (Aim 3.1), blood (Aim 3.2), and pancreatic (Aim 3.3) cancer research networks and then more broadly with collaborators across the cancer research continuum (Aim 3.4). We will work closely with collaborators and users to ensure that we meet the needs of a broad cross-section of the cancer research community that requires transfer, sharing, and analysis of large, human data sets. We will use extensive community outreach through multiple channels to widely disseminate our technologies.