Forging a road to personalized medicine in interstitial lung diseases

描述（由申请人提供）：该奖项的两个主要目标是提高我作为有效导师的能力，同时提供培训，使年轻的研究人员能够成功竞争K23奖和随后的独立资助。一个多样化的教育活动平台，正在进行的研究，以及未来研究的潜力，可以帮助培训肺部医生在面向患者的研究（POR）。在这个奖项期间，我将参加正在进行的教育活动。我将通过参加每周一次的基础科学研究会议来提高我对肺部疾病基础研究的认识。我将学习统计学课程，扩展我在纵向和聚类数据分析、高通量分子、遗传和表观遗传数据分析以及临床试验和生存分析的先进概念方面的知识。我将通过机构审查委员会赞助的课程以及密歇根临床与健康研究所/临床与转化科学奖（MICHR/CTSA）的课程继续接受负责任的研究行为方面的培训。受训者的基本指导计划包括在POR中进行个性化的研究项目，安排导师会议，与统计学家密切合作，针对统计和负责任的研究进行正式的教育活动，以及安排指导团队的正式反馈。澳大多学科培训基金（T32 HL07749-18）以及与MICHR/CTSA的密切合作，提供额外的奖学金后培训和生物统计学和临床研究设计硕士学位。目前资助的研究机会的多样化组合存在于贫穷和贫困地区的未来学员。这些项目结合了已经建立的数据库，可以立即使用，可以将原始数据输入数据库，并能够前瞻性地收集包括患者标本在内的新数据。资助的研究项目包括评估计算机辅助图像分析软件在特发性肺纤维化患者临床试验中的应用，评估潜在生物标志物以预测IPF患者的未来病程，参与IPF临床研究网络和肺组织研究联盟。该申请还提出了两个新的研究项目。第一个项目确定了高分辨率计算机断层扫描特征预测晚期特发性肺纤维化患者对西地那非治疗反应的能力。本研究利用了IPFnet提供的数据。第二个项目将建立一个数据库，并研究人类样本，以提高我们对超敏性肺炎的诊断、预后预测和病理生物学的理解。

DESCRIPTION (provided by applicant): The two main goals of this award are to increase my ability to serve as an effective mentor while also providing training that will allow young investigators to successfully compete for a K23 award and subsequent independent funding. A diverse platform of educational activities, ongoing research, and the potential for future studies are available to aid in the training of pulmonary physicians in patient oriented research (POR). Throughout this award I will participate in ongoing educational activities. I will improve my understanding of the basic study of pulmonary diseases through attending a weekly basic science research conference. I will take statistical courses to expand my knowledge related to analyzing longitudinal and clustered data, high throughput molecular, genetic, and epigenetic data, and advanced concepts in clinical trials and survival analysis. I will continue my training i the responsible conduct of research through institutional review board sponsored courses as well as courses from the Michigan Institute for Clinical & Health Research/Clinical & Translational Science Award (MICHR/CTSA). The basic mentoring plan for trainees includes an individualized research project in POR, scheduled mentor meetings, close collaboration with statisticians, formal educational activities targeting statistics & the responsible conduct of research, and scheduled formal feedback from a mentoring team. The UM Multidisciplinary Training Grant (T32 HL07749-18) and close collaboration with MICHR/CTSA provides funding for additional years of post-fellowship training and a Masters in Biostatistics & Clinical Study Design. A diverse portfolio of currently funded research opportunities exists for future trainees in POR. These projects offer a combination of already established databases for immediate use, raw data that can be maneuvered into databases and the ability to prospectively collect new data including patient specimens. Funded research projects are evaluating the use of computer aided image analysis software for use in clinical trials for patients with idiopathic pulmonary fibrosis, evaluation of potential biomarkers to predict the future course of patients with IPF, participation in the IPF clinical research network and the Lung Tissue Research Consortium. This application also proposes two new research projects. The first project determines the ability of high resolution computed tomography features to predict response to therapy with sildenafil for patients with advanced idiopathic pulmonary fibrosis. This study utilizes data that are available through the IPFnet. A second project will create a database and also study human samples to improve our understanding of the diagnosis, predictors of outcome, and pathobiology of hypersensitivity pneumonia.