Imaging Core

成像核心支持脑出血研究中心三个科学项目的以下具体目标：1)提供脑水肿(T2加权，T2W1)、血液(T2WI和易感加权成像，SWI)的神经成像，脑白质异常的弥散张量成像，使用动态磁化率对比(DSC)和动脉自旋标记(ASL)方法的脑灌注，包括脑血容量(CBV)、脑血流量(CBF)、平均通过时间(MTT)和达峰时间(TTP)指数；2)对收集的成像数据进行分析，包括对水肿和血液、血脑屏障(BBB)破坏、白质变化、脑血流异常的解剖映射；3)为Project PI及其工作人员提供一个集中的位置，以访问原始和分析的数据集；4)开发和实施我们针对其他疾病状态(如中风、脑外伤)所做的计算例程，以自动化和加快分析吞吐量；以及5)为成像数据与行为、细胞生物学和血管结果的比较提供统计和计算支持。我们的综合方法将提供有关蛛网膜下腔出血(SAH)、脑内出血(ICH)和创伤性脑损伤(TBI)三种脑损伤模型之间共同相互关系的新数据。临床神经影像在蛛网膜下腔出血、脑出血和脑外伤的评估中发挥着越来越重要的作用。这些神经疾病状态的一个统一特征是血管外血液的沉积，这对大脑具有极大的毒性，并导致血脑屏障(BBB)的破裂。这种一连串的事件会导致浮肿的发展，往往会带来灾难性的后果。大量研究表明，血液的范围和解剖位置的快速成像对于与潜在的治疗干预相关的决策至关重要。因此，成像核心为这些项目选择了专注于脑损伤和功能的早期和晚期指标：1)浮肿，2)血管外血液，3)脑灌注，4)白质功能。成像核心将1)使用磁共振成像对大脑生理进行非侵入性但功能性的测量，2)使用标准和新颖的计算分析来最大限度地提取数据，以及3)使用数值分析方法从SAH、ICH和脑外伤出现的所有核心(行为、成像、血管)中识别共同的数据。

The Imaging Core supports the following Specific Aims ofthe three scientific projects ofthe Center for Brain Hemorrhage Research: 1) provide neuroimaging for edema (T2-weighted, T2W1), blood (T2WI and suscepribility weighted imaging, SWI), diffusion tensor imaging for white matter abnormalities, cerebral perfusion using both dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) approaches including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) indices; 2) undertake analysis for the collected imaging data, including anatomical mapping of edema and blood, blood brain barrier (BBB) disruption, white matter changes, cerebral perfusion abnormalities; 3) provide a centralized location for Project Pi's and staff to access raw and analyzed datasets; 4) develop and implement computational routines as we have for other disease states (i.e. stroke, TBI) to automate and speed analysis throughput, and 5) provide statistical and computational support for imaging data comparisons to behavior, cell biology and vascular outcomes. Our comprehensive approach will provide novel data about common interrelationships between three brain models of hemorrhagic injury, Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), and Traumatic Brain Injury (TBI). Clinical neuroimaging is increasingly taking a significant role in assessment of SAH, ICH, and TBI. A unifying feature of these neurological disease states is the deposition of extravascular blood which is extremely toxic to the brain and leads to rupture ofthe blood brain barrier (BBB). This cascade of events results in development of edema, often with catastrophic outcomes. Numerous studies have demonstrated that rapid imaging ofthe extent and anatomical location of blood is critical for decision-making relative to potential therapeutic interventions. Thus, the Imaging Core has elected for these Projects to focus on early and late indices of brain injury and function: 1) edema, 2) extravascular blood, 3) cerebral perfusion, and 4) white matter function. The Imaging Core will 1) undertake non-invasive but functional measures of brain physiology using MR imaging, 2) use standard and novel computational analysis to maximize data extraction, and 3) use numerical analysis methods to identify common data from all cores (Behavioral, Imaging, Vascular) that emerge for SAH, ICH, and TBI.