Interstitially Invasive Trophoblast of the Murine Placenta: Developmental Origins, Functions and Gene Expression.

由于研究人类妊娠的明显局限性，小鼠已成为一种有价值的模型。然而，胎盘侵入子宫壁和脉管系统，成功怀孕的关键，在小鼠中知之甚少。该提案的目的是为了更好地了解小鼠的这些过程，并将提供一个更准确的模型系统来研究异常胎盘入侵导致的严重妊娠并发症，如先兆子痫。

Due to the obvious limitations to studying human pregnancy, the mouse has become a valuable model. However, invasion of the placenta into the uterine wall and vasculature, critical for successful pregnancy, is poorly understood in the mouse. The aims of the proposal are designed to gain a better understanding of these processes in mice and will provide a more accurate model system to study serious pregnancy complications resulting from abnormal placental invasion, such as preeclampsia.