Effect of vibration on muscle properties, physical activity and balance in children with cerebral palsy

项目总结/摘要 脑性瘫痪（CP）是一种神经肌肉疾病，在美国影响大约80万人。 肌肉体积、力量和质量、平衡能力差和参与体育活动有限是重要的 CP儿童的健康问题，因为他们与慢性疾病的高风险密切相关。因此，我们认为， 确定解决这些问题的有效治疗策略是当务之急。有一种治疗方法- 高频低幅振动（HLV）是一种受到广泛关注的振动。然而，研究 缺乏HLV对CP儿童肌肉发育、平衡和体力活动的影响。我们长久以来- 长期目标是确定降低CP儿童慢性病风险的治疗方法。总体目标 本申请的目的是确定每日HLV治疗对肌肉体积、力量和质量的影响， 以及非卧床CP儿童的体力活动和平衡。我们的核心假设是，每天的HLV 治疗将增加腿部肌肉体积和力量，减少腿部肌内脂肪，增加体力活动 改善脑瘫儿童的平衡能力为了检验中心假设，我们将追求以下目标：1） 确定每日HLV治疗对患有以下疾病的非卧床儿童的肌肉体积和肌肉力量的影响： CP; 2）确定每日HLV治疗对非卧床CP儿童肌肉质量的影响; 3） 确定每日HLV治疗对非卧床CP儿童体力活动的影响;以及4） 确定每日HLV治疗对非卧床CP儿童平衡的影响。一个随机的骗局- 将使用一个治疗组的受控试验来实现目标。肌肉体积和肌内脂肪 将使用磁共振成像对腿部进行评估。腿部足底屈肌的肌肉力量将 使用测力计进行评估。将使用活动监测器评估体力活动。余额将 使用站立姿势摇摆的测量以及跌倒恢复的测试进行评估。将给予HLV 10 min/d，疗程6个月。这项拟议的研究意义重大，因为患有CP的儿童身材矮小，虚弱和肥胖- 渗透的肌肉，平衡差和低体力活动，使他们处于发展慢性 疾病我们提出了一个创新的干预利用HLV和肌肉支柱的综合评估- 脑瘫儿童的智力、平衡和体力活动。我们希望确定HLV增加肌肉 CP儿童的体型、力量和素质、身体活动和平衡。研究结果将有一个 积极的影响，因为它们将作为建立HLV治疗有效性的关键一步， 与CP儿童患慢性病的高风险作斗争。

PROJECT SUMMARY/ABSTRACT Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000 individuals in the U.S. Low muscle volume, strength and quality, poor balance and limited participation in physical activity are significant concerns in children with CP because they are strongly linked to their high risk of chronic disease. Therefore, identifying effective treatment strategies that address these issues is imperative. One treatment that has re- ceived significant attention is high-frequency, low-magnitude vibration (HLV). However, studies examining the effect of HLV on muscle development, balance and physical activity in children with CP are lacking. Our long- term goal is to identify treatments that reduce the risk of chronic disease in children with CP. The overall objective of this application is to determine the effect of a daily HLV treatment on muscle volume, strength, and quality, as well as physical activity and balance in ambulatory children with CP. Our central hypothesis is that a daily HLV treatment will increase leg muscle volume and strength, reduce leg intramuscular fat, increase physical activity and improve balance in children with CP. To test the central hypothesis, we will pursue the following aims: 1) to determine the effect of a daily HLV treatment on muscle volume and muscle strength in ambulatory children with CP; 2) to determine the effect of a daily HLV treatment on muscle quality in ambulatory children with CP; 3) to determine the effect of a daily HLV treatment on physical activity in ambulatory children with CP; and 4) to determine the effect of a daily HLV treatment on balance in ambulatory children with CP. A randomized con- trolled trial with one treatment arm will be used to accomplish the aims. Muscle volume and intramuscular fat in the leg will be assessed using magnetic resonance imaging. Muscle strength of the leg plantar flexors will be assessed using a dynamometer. Physical activity will be assessed using activity monitors. Balance will be assessed using measures of standing postural sway, as well as tests of fall recovery. HLV will be administered 10 min/d for 6 months. The proposed study is significant because children with CP have small, weak and fat- infiltrated muscles, poor balance and low physical activity which places them at a high risk for developing chronic disease. We propose an innovative intervention utilizing HLV and a comprehensive assessment of muscle prop- erties, balance and physical activity in children with CP. We expect to determine that HLV increases muscle size, strength and quality, physical activity and balance in children with CP. The results of the study will have a positive impact as they will serve as a key step toward establishing the effectiveness of HLV as treatment to combat the high risk of chronic disease in children with CP.