Molecular Mechanisms of Lung Inflammation

描述(申请人提供)：肺部炎症是大多数肺部疾病的核心，包括肺炎、支气管炎、哮喘、纤维化和肺气肿。了解这些疾病背后的分子机制对于我们未来在开发新的治疗策略方面取得成功至关重要。此次NRSA竞争更新旨在将新的基础和临床医学科学家聚集在一起，在研究密集的环境中进行研究，目标是培养下一代致力于了解、预防和治疗肺部疾病的研究人员。这款T32利用俄亥俄州立大学戴维斯心肺研究所、俄亥俄州立大学肺过敏危重护理和睡眠医学部、微生物界面生物学中心和俄亥俄州立大学NIH翻译科学中心奖的培训计划来提供培训平台。我们已经形成了一支具有广泛背景的培训教师队伍，以支持在肺宿主防御、细胞凋亡损伤和修复、分子遗传学、细胞信号转导和转化医学方面的特定体验机会。我们的计划是在一个为期两年的项目中一次招聘2名博士后和2名医学博士实习生，该项目提供一种创新的体验，培养跨学科的理解，并在密集和创造性的环境中将这些实习生与初级和高级教师联系起来，以促进未来的肺部疾病研究职业生涯。具体地说，该方案的目标有四个。目的1.在分子生物学、免疫学、细胞信号、蛋白质组学和功能基因组学方面提供足够的讲授、互动和技术背景，使受训者能够在这些学科之间轻松移动，并能够将他们的知识转化为对肺部疾病起源的进一步了解。目标2.制定一项创新计划，确保受训者迅速进入有可能成功的实验室体验。此外，通过同行评议和跨学科的教师监督，我们将在整个培训期间向学员灌输一致的势头，并专注于他们选择的研究主题。目标3.使受训者沉浸在创造性的环境和积极的研究氛围中，以确保最大可能在科学研究人员队伍中取得成功并留住他们 还有老师。此外，还将提供研究伦理和研究哲学方面的具体培训，目的是培养能够在最高水平的学术诚信下开展工作的科学家。目标4.制定长期计划，鼓励妇女和少数民族从事肺部科学和研究事业，更重要的是，在培训计划内建立足够的基础设施和支持系统，以确保有动力的受训者取得成功。(摘要结束)

DESCRIPTION (provided by applicant): Lung inflammation is central to the most lung diseases which include pneumonia, bronchitis, asthma, fibrosis and emphysema. Understanding the molecular mechanisms underlying these diseases is critical to our future success in developing new treatment strategies. This NRSA competitive renewal is designed to bring new basic and clinical medical scientists together to study in a research intensive environment with the goal of generating the next generation of investigators working to understand, prevent and treat lung disease. This T32 utilizes the infrastructure of the Ohio State University's Davis Heart and Lung Research Institute, the OSU Pulmonary Allergy Critical Care and Sleep Medicine Division, the Center for Microbial Interface Biology and the training programs of the OSU NIH Center for Translational Sciences Award to provide the training platforms. We have formed a training faculty with broad backgrounds to support specific experience opportunities in lung host defense, apoptosis injury and repair, molecular genetics, cell signaling, and translational medicine. Our plan is to recruit 2 postdoctoral Ph.D. and 2 M.D. trainees at a time into a 2 year program that provides an innovative experience that breeds interdisciplinary understanding and links these trainees with both junior and senior faculty in an intensive and creative environment that promotes future research careers in lung disease. Specifically the objectives of the program are fourfold. Objective 1. To provide sufficient didacti, interactive and technical background in molecular biology, immunology, cell signaling, proteomics and functional genomics to allow trainees to be able to move easily between these disciplines and to be able to translate their knowledge into further understanding of the origins o pulmonary disease. Objective 2. To develop an innovative program which ensures that trainees move rapidly into laboratory experiences that are likely to be successful. Furthermore, by using peer review and interdisciplinary faculty oversight, we will instill in the trainees a consistent momentum and focus on their chosen research topics throughout the training period. Objective 3. To immerse the trainees in a creative environment and positive research atmosphere which ensures the greatest possibility for success and retention in the ranks of scientific investigators and teachers. In addition, specific training will be provided in the ethics and philosophy of research with the intent of producing scientists who will operate at the highest levels of intellectual integrity. Objective 4. To develop long-range programs which encourage women and minorities to pursue careers in pulmonary science and research and more importantly, to build sufficient infrastructure and support systems within the training program to ensure the success of the motivated trainee. (End of Abstract)