CoBRE for Signal Transduction and Cancer Phase III

我们的长期目标是在西弗吉尼亚州和周边的阿巴拉契亚地区建立一个NCI指定的癌症中心。西弗吉尼亚大学（WVU）是该州的旗舰大学和医疗中心，目前西弗吉尼亚没有被NCI指定的癌症中心。我们的I-II期cobre用于信号转导和癌症（P20），旨在支持基础研究发展。WVU Mary Babb Randolph癌症中心（MBRCC）成功竞争癌症中心支持拨款（CCSG）和NCI指定的关键组成部分。我们第一阶段和第二阶段cobre的具体目标从最初关注初级研究人员，主要目标是培养职业发展和独立资助（第一阶段），发展到第二阶段继续支持初级研究人员，并在目标主题领域建立临界质量。此外，关键核心设施的建立和加强在I-II阶段得到了支持，这一关键核心和基础设施支持的最后阶段确定了我们第三阶段（PSO）过渡奖的重点。

Our long term goal is to establish an NCI designated cancer center for West Virginia (WV) and the surrounding Appalachian region. West Virginia University (WVU) is the flagship university and medical center in the state with no cancer centers in WV currently having NCI designation. Our Phase I-II CoBREs for Signal Transduction and Cancer (P20) were designed to support basic research development as a .critical component of successfully competing for a Cancer Center Support Grant (CCSG) and coincident NCI designation for the WVU Mary Babb Randolph Cancer Center (MBRCC). The specific aims of our Phase I and Phase II CoBREs evolved from an initial focus on junior investigators with a primary goal of nurturing career development and independent funding (Phase I) to a combination of continued support of junior investigators with establishment of a critical mass in targeted thematic areas during Phase II. In addition, the establishment and strengthening of essential core facilities was supported during Phases I-II and the final stage of this critical core and infrastructure support defines the focus of our Phase III (PSO) Transition Award. Established scientific thematic areas in the MBRCC include Programs focused on the Molecular Mechanisms of EMT and Metastasis, Breast Cancer, Hematopoietic Malignancies and Transplantation, and Translational Tobacco Reduction Research. These Programs provide a structured atmosphere for collaboration and mentoring for the MBRCC members and the platform in which to shape multi-investigator and programmatic grant applications. Relevant to this Transition Award application, projects throughout all of these Programs are supported by the Cores for which support is requested: Flow Cytometry, Microscope Imaging, Animal Models and Imaging, Protein, Biostatistics and Bioinformatics, and Biospecimen Processing. The specific aims of this Phase III Transition Award include (1) support of state-of-the-art technology and expertise in sustainable core facilities that emphasize accessibility and training in which we nurture career development of investigators undertaking cancer related research and (2) enhanced collaboration in the MBRCC, WVU and the state to maximize the impact of CoBRE investment to ensure maximum access to technology required for high quality, extramurally funded research. Emphasis has been placed on strategies to support collaboration, sustainability, and an avoidance of redundant investment to yield the greatest impact of this award on continued growth of the MBRCC, in part, through availability of outstanding core facility support. Collectively, these efforts support our long-term goal of NCI designation.