Intracellular trafficking of copper and platinum-based chemotherapuetics

以铂为基础的抗癌药物，如顺铂，对许多头部、结肠癌、肺癌和卵巢癌有效。肿瘤对这些药物的耐药性与控制铜进出细胞的基因的变化密切相关。我们假设相同的基因同时调控铜和顺铂的分布。通过研究这些途径，我们的目标是找到预测和预防肿瘤对这种重要的抗癌治疗的耐药性的方法。

Platinum-based anti cancer drugs such as Cisplatin are effective against a number of cancers of the head, colon, lungs and ovaries. Tumour resistance to these drugs has been closely associated with changes in genes that control the movement of copper in and out of cells. We hypothesize that the same genes regulate distribution of both copper and Cisplatin. By investigating these pathways, we aim to find ways to predict and prevent tumour resistance to this important anti cancer treatment.