Intranasal naloxone for the reversal of opioid overdose: A double-blinded, double-dummy controlled non-inferiority trial in Sydney’s Medically Supervised Injecting Centre

纳洛酮鼻内给药与其他给药途径相比具有许多优点，特别是与带回家的纳洛酮（THN）相关，因为它避免了使用针头的并发症，例如针头损伤的风险，并且需要较少的培训。新的数据表明，它可能与肌内纳洛酮一样有效。我们将在悉尼医学监督注射中心的临床实践中进行一项非劣效性对照试验来检验这一假设。

The intranasal administration of naloxone confers many advantages over other routes of administration, particularly in relation to take home naloxone (THN) as it avoids complications with the use of needles such as the risks of needle-stick injury and requires less training. New data suggests that it may be as effective as intramuscular naloxone.We will test this hypothesis in a non-inferiority controlled trial conducted in clinical practice at the Sydney Medically Supervised Injecting Centre.