UT southwestern O'Brien Kidney Research Core Center

这是乔治·M·奥布莱恩肾脏研究核心中心在华盛顿大学的续签申请 位于达拉斯的德克萨斯西南医疗中心。主任是内科教授Peter Igarashi博士 医学和儿科，德克萨斯大学西南分校肾病科主任。该计划的总体目标 中心的目标是促进基础科学家和临床研究人员之间的双向互动，这将 从根本上提高我们对肾脏发育和病理生理的了解，并导致更多 有效治疗慢性肾脏疾病及其并发症。为实现这一目标，该中心支持 生物医学研究核心，试点和可行性补助金，以及教育充实计划。四个 生物医学研究的核心是：1)动物模型，2)生理学，3)细胞生物学与成像，4)临床 &翻译研究。这些核心支持德克萨斯大学49名研究人员进行的肾脏研究 西南大学，德克萨斯州北部和中部的其他三所学术机构，以及一所 正式隶属于德克萨斯大学西南分校。研究的领域是肾脏发育和 遗传学、肾脏生理学和病理生理学，以及慢性肾脏疾病。此外，其中三个核心 提供校外肾脏研究人员广泛使用的服务或试剂 遍布美国和世界各地的机构。自2007年成立以来，该中心一直支持 111篇已发表的论文以及新的科学合作和拨款申请。这些研究是 为先天性心脏病的发病机制和治疗提供了新的见解 肾脏异常、多囊肾病、狼疮性肾炎、糖尿病肾病、电解质 慢性肾脏疾病的紊乱和并发症。为了扩大肾脏研究人员的队伍， 中心每年向来自以下机构的新调查人员或现有调查人员颁发两次试点和可行性补助金 其他字段。教育充实计划包括每月一次的研究研讨会、年度研讨会、 培训补助金，以及通过部门提供的课程。临床科学以及实践动手能力 在每个核心进行培训。

This is an application for renewal of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology at UT Southwestern. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will fundamentally advance our understanding of kidney development and pathophysiology and result in more effective treatments of chronic kidney disease and it complications. To achieve this goal, the Center supports Biomedical Research Cores, Pilot & Feasibility Grants, and an Educational Enrichment Program. The four Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology & Imaging, and 4) Clinical & Translational Research. The Cores support kidney research that is conducted by 49 investigators at UT Southwestern, three other academic institutions in North and Central Texas, and a foreign institution that is formally affiliated with UT Southwestern. Research is conducted in the areas of kidney development & genetics, renal physiology & pathophysiology, and chronic kidney disease. In addition, three of the Cores provide services or reagents that are widely utilized by off-campus kidney researchers located at numerous institutions throughout the U.S. and worldwide. Since its establishment in 2007, the Center has supported 111 published articles as well as new scientific collaborations and grant applications. Studies that are supported by the Center have provided new insights into the pathogenesis and treatment of congenital kidney abnormalities, polycystic kidney disease, lupus nephritis, diabetic nephropathy, electrolyte disturbances, and complications of chronic kidney disease. To expand the pool of kidney researchers, the Center awards two Pilot & Feasibility Grants per year to new investigators or established investigators from other fields. The Educational Enrichment Program includes a monthly research seminar, annual symposium, training grants, and courses offered through the Dept. of Clinical Sciences as well as practical hands-on training in each of the Cores.