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Antiviral host defense through selective translational inhibition

Antiviral host defense through selective translational inhibition
通过选择性翻译抑制进行抗病毒宿主防御
批准号：
8914843
负责人：
MICHAEL DAVID
金额：
$0.84万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-06-01 至 2016-05-31
来源：
https://reporter.nih.gov/project-details/8914843
关键词：
AIDS/HIV problemATP phosphohydrolaseAffectAlternative SplicingAnti-Retroviral AgentsAntigensAntiviral AgentsAntiviral ResponseAreaAttenuatedBindingBiogenesisBiological ProcessCaenorhabditis elegansCellsChargeCodon NucleotidesCommunicable DiseasesDNADevelopmentDiagnosticDiseaseDominant-Negative MutationDrosophila genusERG geneEmployee StrikesEventFamilyGenerationsGenesGenetic TranscriptionGoalsHIVHIV InfectionsHomologous GeneHost DefenseHumanIRF3 geneImmune responseInfectionInfection preventionInfluenzaInterferon-alphaInterferon-betaInterferonsKineticsLengthLightLocationMediatingMessenger RNAMolecularMolecular Mechanisms of ActionMulti-Drug ResistanceMusN-terminalNucleic Acid BindingOrganismPathway interactionsPharmaceutical PreparationsPositioning AttributePoxviridaeProcessProductionProtein BindingProtein BiosynthesisProtein InhibitionProtein IsoformsProtein Synthesis InhibitionProteinsRNA HelicaseReportingRetroviridaeReverse TranscriptionRoleShapesSpecificityStagingSystemTestingTherapeuticTherapeutic InterventionTransfer RNATranslational RepressionViralViral ProteinsVirusYeastsbasemembermicrobialnovelpathogenpreferenceprognosticprospectiveprotein expressionprotein functiontoolviral RNA

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相关文献

中文摘要
翻译
描述（由申请人提供）：艾滋病毒仍然是世界上最流行的传染病之一。我们发现了一种新的细胞因子，可以抑制感染细胞产生HIV，这为开发新型抗病毒药物提供了新的靶点，并可能具有诊断和预后价值。此外，基于抗病毒活性的分子基础，我们假设其他病毒如流感病毒也会受到huSlfn11的抑制。
英文摘要
DESCRIPTION (provided by applicant): HIV continues to be one of the most prevalent infectious diseases in this world. Our discovery of a novel cellular factor that inhibits the production of HIV by infected cells provides a new target for the development of a novel class of anti-viral drugs and may additionally carry diagnostic and prognostic value. Furthermore, based on the molecular basis of the antiviral activity we hypothesize that other viruses such as Influenza will also be subject to inhibition by huSlfn11.
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会议论文
Translational inhibition by Schlafen proteins during the DNA damage response
The IRF-type I interferon system during gestation
DNA structure modification by the Schlafen protein family
Role of TLR3 pathway in HIV infection