Investigatin the causes of failed efferocytosis in COPD-emphysema with a view to identifying novel theraputic targets

慢性阻塞性肺病是导致死亡的主要原因。吸烟是慢性阻塞性肺疾病的主要原因，许多患者会受到永久性的损害，即使在戒烟后也需要持续的治疗。目前治疗慢性阻塞性肺疾病的方法通常疗效有限。该项目将确定我们在COPD患者呼吸道中发现的大量死亡细胞和这些细胞清除缺陷的原因，并研究新的治疗方法，我们希望这些治疗方法将改善COPD患者的健康和福祉。

COPD is a leading cause of death. Smoking is the major cause of COPD and many sufferers are left with permanent damage and need ongoing treatment even after smoking cessation. Current treatments for COPD generally have limited efficacy. The project will identify the reason for the large number of dying cells and defective clearance of these cells that we have identified in the airways in COPD and study novel treatments that we hope will improve the health and well being of those with COPD.