Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders

描述(申请人提供)：睡眠医学是一门相对较新的学科。因此，很少有机构拥有足够多的教员来提供单一的机构培训拨款。他说，缺乏研究培训是睡眠医学领域利用当前科学机会的一大障碍。新科学有很大机会的一个领域是遗传/基因组方法领域。这些都是开发个性化睡眠药物所必需的。许多睡眠障碍是可遗传的，尽管导致风险的基因变异在很大程度上是未知的。此外，最近在许多物种中发现了类似睡眠的状态，如蠕虫、果蝇、斑马鱼和老鼠。这些模型系统可以用来确定在人类研究中识别的基因变异的功能意义。为了利用这些机会，提出了一项新的国家努力。其基础是涉及三个机构--约翰霍普金斯大学、斯坦福大学和密歇根大学的多机构培训赠款。该项目将由宾夕法尼亚大学指导，这三个机构都有研究员。宾夕法尼亚大学在睡眠研究培训方面拥有最丰富的经验，并拥有重要的行政和培训基础设施来支持这一计划。该计划将侧重于培养下一代内科科学家。学员将在该计划的支持下接受为期三年的培训。将有一个核心课程，供所有受训人员学习。这将使用已经投入使用的基于视频的新IT技术。核心课程将包括以下内容：讲座 所有参与机构的教师关于睡眠及其障碍的遗传学/基因组学；CAREE开发；赠款研讨会；期刊俱乐部；受训人员正在进行的研究演讲。每个学员都将在他们的母校有共同的导师--一名睡眠研究专家和一名遗传学/基因组学专家。他们还将有一个由睡眠研究和遗传学专家组成的指导委员会。对于导师委员会，如果合适的话，将有来自该项目中各个机构的导师，以及来自目前资助睡眠研究培训计划的机构(哈佛、宾夕法尼亚、匹兹堡)的导师。在这些其他机构从事基因/基因组研究的受训人员也将被视为这一国家努力的一部分。所有实习生和教职员工将举行年度务虚会。这将引导新学员获得研究机会，并允许更多高级学员展示他们的研究成果。还将有学员挑选的主旨演讲者。这一撤退将促进 所有不同地点的实习生。这项全国性努力的目标是培养一支新的研究队伍，研究基因/基因组方法对睡眠及其障碍的影响。

DESCRIPTION (provided by applicant): Sleep medicine is a relatively new discipline. Hence, few institutions have the critical mass of faculty to mount a single institutional training grant. he lack of research training is a major barrier for the field of sleep medicine to take advantage of current scientific opportunities. One area where there are substantial opportunities for new science is in the field of genetic/genomic approaches. These are needed to develop personalized sleep medicine. Many sleep disorders are heritable, although the gene variants that confer risk are largely unknown. Moreover, recently sleep-like states have been identified in many species such as worms, fruit flies and zebra fish as well as mice. These model systems can be used to determine the functional significance of gene variants identified in human studies. To capitalize on these opportunities, a novel national effort is proposed. The basis of this is a multi-institutional training grant involving three institutions-Johns Hopkins, Stanford University and University of Michigan. The program will be directed by the University of Pennsylvania with fellows at each of these three institutions. The University of Pennsylvania has the most experience in research training in sleep and has significant administrative and training infrastructure to support this program. The program will focus on training the next generation of physician-scientists. Trainees will be given three years of training supported by this program. There will be a core curriculum that will be taken by all trainees. This will use new video-based IT technology that is already operational. The core curriculum will involve the following: lectures on genetics/genomics of sleep and its disorders by faculty at all participating institutions; caree development; grants workshop; journal club; research-in-progress talks by trainees. Each trainee will have co- mentors at their home institution-one expert in sleep research and one in genetics/genomics. They will also have a mentorship committee with experts in sleep research and genetics. For the mentorship committee, mentors from the various institutions in this program, as well as from institutions that currently have funded training programs in sleep research (Harvard, Penn, Pittsburgh) will be involved, if appropriate. Trainees who pursue genetic/genomic research at these other institutions will also be considered part of this national effort. There will be an annual retreat of all trainees and faculty. This will orient new trainees o research opportunities and allow more advanced trainees to present their research. There will also be keynote speakers selected by trainees. This retreat will facilitate interaction between the trainees at all the different sites. The goal of this national effort is to develop a cadre of new investigators in genetic/genomic approaches to sleep and its disorders.