The same dysarthria in different languages: Hypokinetic dysarthria in English and

描述（由申请人提供）：我们对构音障碍的了解主要基于神经病理生理学标签，如弛缓或运动功能减退，这些标签被认为可以“解释”言语产生特征（以及相关的可懂度缺陷）。然而，这一理论最近受到了挑战的实验数据报告之间的神经病理生理学和语音特征的不匹配。此外，事实上，大多数构音障碍的研究已经进行了美国英语的发言者也有助于神经病理学和语音输出之间的联系的不确定性。 为了解决这个问题，本项目提出了一个单一的，经常研究构音障碍的语音特征的母语的影响的检查。这种方法的假设是，它可以阐明语言通用方面的构音障碍和语言特异性方面的构音障碍之间的区别。首先，我们建议获得两种语言（美国英语和韩语）内的声学和清晰度的措施，以产生一组紧密匹配的声学措施，并构建基于声学的语音清晰度预测模型，在每种语言。为此目的，声学分析将进行由讲英语和讲韩语的个人与帕金森病和运动减退性构音障碍的话语。语音清晰度的预测模型将在两种语言之间进行比较，假设有助于语音清晰度变化的变量的权重在语言之间会有所不同。我们还建议调查帕金森病的语音的第二个感知方面，判断的听众谁回应他们的母语和非母语的话语。为此目的，将要求听众在听他们理解的话语（说话者和听众之间的母语匹配）和他们不理解的话语（说话者和听众的母语之间的不匹配）时对患有运动减退性构音障碍的说话者的多个语音维度进行评级。 这种治疗构音障碍的新方法的结果有望：1）扩展我们对构音障碍性质的基本知识，2）为为什么在构音障碍的临床评估和管理中应考虑语音/语言变异提供理论基础。

DESCRIPTION (provided by applicant): Our knowledge of dysarthria is largely based on neuropathophysiologic labels such as flaccidity, or hypokinesia, which are assumed to "explain" speech production characteristics (and associated intelligibility deficits). However, this theory has been recently challenged by experimental data reporting mismatches between neuropathophysiology and speech characteristics. In addition, the fact that the majority of dysarthria studies have been conducted on speakers of American English also contributes to the uncertainty about the link between neuropathology and speech output. To address this concern, this project proposes an examination of the effect of native languages on speech characteristics of a single, often-studied dysarthria. The assumption of this approach is that it can shed light on the distinction between language-universal aspects of dysarthria and language-specific aspects of dysarthria. First, we propose obtaining acoustic and intelligibility measures within two languages (American English and Korean) to yield a closely matched set of acoustic measures and construct acoustically-based predictive models of speech intelligibility, within each language. For this aim, acoustic analysis will be performed on utterances produced by English-speaking and Korean-speaking individuals with Parkinson disease and hypokinetic dysarthria. The predictive models of speech intelligibility will be compared between the two languages, with the hypothesis that the weights of the variables contributing to speech intelligibility variation will differ between languages. We also propose to investigate a second perceptual aspect of speech of Parkinson disease, as judged by listeners who respond to utterances both in their native and non-native languages. For this aim, listeners will be asked to rate multiple speech dimensions of speakers with hypokinetic dysarthria, while listening to utterances they understand (native language match between speakers and listeners) and utterances they do not understand (mismatch between native language of speakers and listeners). The results from this novel approach to dysarthria are expected 1) to extend our fundamental knowledge about the nature of dysarthria, and 2) to provide a theoretical basis as to why speech/language variations should be considered in clinical assessment and management of dysarthria.