Investigating the contribution of distinct mitochondrial cell death pathways to platelet survival and function

血小板是一种小的血细胞，可以形成血栓来止血。我们发现了两种不同的途径在血块形成过程中调节细胞死亡的新的和意想不到的作用。我们将研究这些途径在血凝块形成中的确切作用，并确定它们是否也可以调节血库储存的血小板的存活。这些研究将为细胞死亡途径在血凝块形成中的作用提供新的见解，并可能有助于改善目前储存血小板的方案

Platelets are small blood cells that form clots to stop bleeding. We have found new and unexpected roles for 2 distinct pathways that regulate cell death in the process of blood clot formation. We will study the precise role of these pathways in blood clot formation, and determine whether they may also regulate the survival of platelets stored by the blood bank for transfusion. These studies will provide new insight into the role of cell death pathways in blood clot formation, and may help to improve current protocols for storing platelets