Investigating Cytoskeletal Dynamics Across the Lifecycle of the Malaria Parasite

在其生命周期中，疟疾寄生虫必须在两种截然不同的宿主——人类和蚊子——体内穿越组织并侵入细胞。虽然我们知道驱动这一过程的分子，但我们对它们在活体寄生虫中的动态一无所知。在这里，我们将使用最先进的显微镜和遗传学来解剖寄生虫的运动，跟踪寄生虫细胞中的蛋白质从人类宿主到蚊子的旅程-利用澳大利亚第一个疟疾专用昆虫。

During its lifecycle the malaria parasite must cross tissues and invade cells in two very different hosts - humans and mosquitos. Although the molecules that drive this process are known, we know nothing about their dynamics in live parasites. Here, we will use state-of-the art microscopy and genetics to dissect parasite motility, tracking proteins in the parasite cell on their journey from human host through to the mosquito - utilising the first Australian malaria-dedicated insectary.