Interactive Technology for Pediatric HIV/AIDS Treatment Adherence

描述(由申请人提供)：这项研究的目的是评估使用最先进的视频游戏技术来提高13-24岁HIV+青少年和年轻人(Aya)依从性的可行性和可接受性。在这一特殊人群中，治疗疲劳和提高独立性的愿望可能导致不遵守，这可能导致抗药性艾滋病毒--这是艾滋病毒护理领域的一个严重问题。通过传统的健康信息很难联系到Aya，但他们对视频游戏的参与度很高。这个项目的目标是利用这种强烈的动机玩游戏来提高服药依从性。以前的行为改变游戏已经显示出积极的结果，利用游戏的引人注目的性质，使健康教育变得有趣，并改变对疾病和治疗的态度和情绪。这种干预包括了所有这些元素，但超越了这些元素，还有一项新的创新，它改变了视频游戏被用来遵守的方式。预期的结果是一种新的治疗方法，它作为一种适销对路的产品的基础，以及一种有效的、基于证据的行为干预措施，可以提高HIV+Aya患者对治疗的依从性。我们的多学科团队将招募HIV+Aya来协助开发智能手机/网络视频游戏原型。我们将通过目标受众以及他们的父母和医疗保健提供者的反复投入来制定干预措施，以提高可接受性。我们将进行可行性测试和修改，以提高游戏的性能和可接受性。我们将试行一项干预措施，以评估奥运会对未加入HIV+Aya的人在6个月内遵守措施的影响。我们将评估游戏的可接受性和对依从性的影响，通过生物结果来衡量，如CD4计数和病毒载量。我们预计结果将证明可行性，这将提供数据，为第二阶段研究提供数据，以测试 通过一项更大规模的随机对照试验，游戏在提高依从性方面的有效性，以及在可玩性、艺术和动画风格、玩家参与度和总体可接受性方面提供更显著的反馈。这些目标的成功实现将表明，该产品将如何促进对艾滋病毒+青少年艾滋病毒/艾滋病治疗和护理的循证行为干预的有效实施。这项核心技术也可以进行修改，以应用于其他医疗条件。

DESCRIPTION (provided by applicant): This study will aim to assess the feasibility and acceptability of using state-of-the-art video game technology to increase adherence among HIV+ adolescents and young adults (AYA) ages 13- 24. Treatment fatigue and the desire for increasing independence among this particular population can lead to non-adherence, which can result in treatment-resistant HIV-a critical problem in the field of HIV care. AYA can be hard to reach with conventional health messaging, yet they respond to video games with a high level of engagement. The goal of this project is to harness this strong motivation to play games to improve medication adherence. Previous games for behavior change have shown positive results by using the compelling nature of gameplay to make health education entertaining and to shift attitudes and emotions about the illness and the treatment. This intervention includes all those elements, but goes beyond them with a new innovation which changes the way video games are used for adherence. The intended result is a novel therapeutic which serves as the basis for a marketable product and an effective, evidence-based behavioral intervention that increases adherence to treatment in HIV+ AYA. Our multidisciplinary team will recruit HIV+ AYA to assist in informing the development of prototype smartphone/Web video games. We will develop the intervention with repeated input from the target audience, as well as among their parents and healthcare providers, to increase acceptability. We will conduct feasibility testing and revisions to increase game performance and acceptability. We will pilot an intervention to assess the impact of the games on adherence measures among non-adherent HIV+ AYA over a 6-month period. We will assess the games' acceptability and impact on adherence as measured through biological outcomes such as CD4 count and viral load. We anticipate the results will demonstrate feasibility which will provide data to inform a Phase II study to test the efficacy of the game on increasing adherence through a larger randomized controlled trial as well as provide a more significant level of feedback on playability, art and animation styles, player engagement, and overall acceptability. Successful completion of these aims will demonstrate how this product might advance the effective implementation of an evidence-based behavioral intervention for HIV/AIDS treatment and care among HIV+ youth. The core technology could also be revised to be applied to other medical conditions.