Impact of mastitis in breast cancer formation

乳房炎是哺乳期常见的乳房感染。乳房炎要么是感染性的，要么是乳汁淤积引起的，导致乳房细胞外基质或间质发炎。乳房炎可通过治疗缓解，但会导致乳腺小叶退缩。众所周知，乳房炎发作会增加患乳腺癌的风险。此外，在哺乳期后，乳腺癌的风险增加，与乳房炎无关。这在一定程度上是由于炎症基因在退化过程中的诱导。该项目旨在确定乳腺癌是否更容易在乳房炎后的环境中发展。使用高通量技术，我们的目标是定义乳房炎在细胞外基质(间质)中诱导的急性和慢性变化，以及这些变化如何促进乳腺癌的形成。最后，我们的目标是确定乳房炎对乳腺间质中PTHrP信号的影响，以及PTHrP通过对乳腺干细胞的影响而促进乳腺癌的作用。作为基质生物学科布雷的一名初级研究员，我将与我的科学导师合作，完成科学目标，并为未来的R01资金制定一项赠款提案。

Mastitis is a common infection ofthe breast during lactation. Mastitis is either infective or due to milk stasis and induces inflammation in the extracellular matrix or stroma of the breast. Mastitis resolves with treatment but causes involution of mammary lobules. Episodes of mastitis are known to increase the risk of breast cancer. Moreover, in the post-lactation period, the breast cancer risk is increased, independent of mastitis. This is in part due to the induction of inflammatory genes during the process of involution. This project aims to determine if breast cancer develops more readily in a post-mastitis milieu. Using high-throughput technologies, we aim to define the acute and chronic changes that mastitis induces in the extracellular matrix (stroma) and how these changes contribute to the formation of breast cancer. Lastly, we aim to define the effects of mastitis on PTHrP signaling in the mammary stroma and PTHrP's role in promoting breast cancer via its effects on mammary stem cells. As a Junior Investigator in the COBRE in Matrix Biology, I will work with my scientific mentor to complete the scientific aims and to develop a grant proposal for future R01 funding.