PROJECT F

项目F：mRNA加工的遗传学; Joel H.格雷伯（杰克逊） 一个完整的基因调控模型需要理解从DNA到表达的所有阶段的控制 从mRNA到最终的蛋白质产物。对环境变化的反应，如饮食，涉及改变 在多个激活阶段表达。转录后加工差异的遗传基础， 例如可变剪接和可变多聚腺苷酸化，仍然知之甚少。遗传限定 小鼠品系，如DO和RIX，提供了一种强有力的方法来研究基因组中的遗传差异。 表达和调节以响应环境中受控的变化。与以下机构合作： 项目C，D和E，我们将研究mRNA加工的遗传差异，以响应饮食 正常食物、高维生素D含量和高脂肪含量之间的差异。

Project F: Genetics of mRNA processing; Joel H. Graber (Jackson) A complete model of gene regulation requires understanding control at all stages of expression from DNA through mRNA to final protein product. Response to environmental changes, such as diet, involves changes in expression at multiple stages of activation. Genetic bases for differences in post-transcriptional processing, such as alternative splicing and alternative polyadenylation, remain poorly understood. Genetically defined strains of mice, such as the DO and RIX, provide a powerful means of investigating genetic differences in gene expression and regulation in response to controlled changes in environment. Working in collaboration with projects C, D, and E we will investigate genetic differences in mRNA processing in response to dietary variation between normal chow, high vitamin D content, and high fat content.