Global Health Research and Training in malaria and cholera: opportunities for nov

描述(由申请人提供)：当前提案的目标是通过参与以患者为导向的研究，为研究员、医学生和本科生提供全球卫生职业生涯的指导。这项研究将在加纳和海地的国际卓越研究地点与稳固的合作者一起进行。这些项目将来自由NIH R01和两个比尔和梅林达·盖茨大挑战探索奖资助的研究。这些项目将在从长凳过渡到床边的高度创新的临床转化研究方面提供经验。具体项目是：(1)内皮祖细胞与脑型疟疾的发病机制(2)重新布线肠道信号以预防霍乱(3)用于诊断疟疾的无创手机成像探头。这些项目的合作研究团队包括来自不同领域的科学家，如干细胞生物学和工程学，与内科科学家协同工作。在了解疟疾发病的基本机制或开发疟疾和霍乱的新诊断和预防方法方面，个人的共同目标是一致的。学员参与这些项目的经验将为他们未来参与多学科合作的全球卫生研究做好准备。与互补的教学研究相结合，他们将做好充分准备，在这一领域取得重大进展。此外，该提案将提供至关重要的资金，使我能够继续为这些类型的职业教授和培训那些在全球卫生“流水线”中的人。

DESCRIPTION (provided by applicant): The goal of the current proposal is to provide mentorship for fellows, medical students and undergraduates for careers in global health through participation in patient-oriented research. The research will be conducted with firmly established collaborators at international sites of research excellence in Ghana and Haiti. The projects will stem from research funded by an NIH R01 and two Bill and Melinda Gates Grand Challenge Exploration Awards. These projects will provide experiences in highly innovative clinical translational research in transition from the bench to the bedside. The specific projects are: (1) Endothelial progenitor cells and the pathogenesis of cerebral malaria (2) Re-wiring enteric signaling for preventing cholera (3) A noninvasive cell phone imaging probe for diagnosing malaria. The collaborative research teams for these projects involve scientists from disparate fields such as stem cell biology and engineering working in concert with physician-scientists. The individuals are united in common goals of understanding basic mechanisms of malaria pathogenesis or the development of novel diagnostics and prophylactics for malaria and cholera, respectively. The experiences of trainees participating in these projects will prime them for futures in multidisciplinary collaborative global health research. Combined with complementary didactic studies they will be well prepared to make major advances in this field. In addition, the proposal will provide vital funding to permit me to continue to teach and train those in the global health "pipeline" for these types of careers.