Integrative Cardiovascular Pathophysiology

描述(由申请人提供)：此续签申请请求支持心血管病理生理学(ICVP)综合培训计划的博士后和博士后学员。ICVP培训计划的教师导师在坦普尔大学医学院心血管研究中心(由ICVP计划主任Steven Houser博士指导)或转化医学中心(由ICVP计划联席主任Walter Koch博士指导)任职。我们项目的目的是在综合心血管病理生理学(ICVP)领域为博士后研究员、博士后研究员和暑期医学生提供广泛的多学科培训经验。ICVP的教职员工居住在许多不同的基础科学和临床科室，但他们的研究实验室位于CVRC和CTM内，这两个实验室位于一座新的医学研究大楼的两层相邻楼层。ICVP研究人员/导师对心血管系统的基本特性以及这些特性的异常变化在包括缺血性心脏病、高血压性心脏病、动脉粥样硬化、缺血性血管疾病、代谢综合征和糖尿病心血管疾病在内的疾病中导致心血管功能障碍有相关兴趣。研究生和博士后研究员将接受人类生理学和病理生理学的教学培训，并辅之以细胞和分子生物学的高级培训，以及适当使用人类心血管疾病的动物模型。研究生和其他研究项目将包括基本部分和翻译部分。学生和研究员将被期望研究超出单个分子的问题，并在心血管疾病模型的背景下解决问题。这些项目的不同部分将在不同研究人员的实验室进行，确保学生和研究员接触到不同的科学方法。所有学员将参加活动，以提高他们的赠款和手稿写作和口头沟通的技能。初级和高级教员的小组辅导将确保受训人员具有良好的资质，能够担任能够快速翻译的首席调查人员 将新知识带入临床实践。将使用各种招聘策略来吸引 不同的受训人员群体，反映了我国的多样性。我们的目标是让一批不同的新博士毕业。以及博士后研究员，他们能够满足国家对新的生物医学科学家的需求，以提供下一代疗法，以减少心血管疾病的影响。

DESCRIPTION (provided by applicant): This renewal application requests support for pre- and post-doctoral trainees in an Integrated Cardiovascular Pathophysiology (ICVP) training program. Faculty mentors in the ICVP training program have their appointments within the Cardiovascular Research Center (Directed by Dr. Steven Houser, ICVP program director) or the Center for Translational Medicine (directed by Dr. Walter Koch, Co-Director of the ICVP program) at Temple University School of Medicine. The purpose of our program is to provide a broad based multidisciplinary training experience for pre- doctoral fellows, post-doctoral fellows and summer medical students in the area of integrative cardiovascular pathophysiology (ICVP). ICVP faculty members reside with many different basic science and clinical Departments, but their research laboratories are within the CVRC and CTM which are housed on two adjacent floors of a new medical research building. ICVP investigators/mentors have related interests in fundamental properties of the cardiovascular system and the aberrant changes in these properties that cause cardiovascular dysfunction in diseases including ischemic heart disease, hypertensive heart disease, atherosclerosis, ischemic vascular disease, metabolic syndrome and diabetic cardiovascular diseases. Graduate students and post-doctoral fellows will receive didactic training in human physiology and pathophysiology, complemented by advanced training in cellular and molecular biology and the appropriate use of animal models of human cardiovascular disease. Graduate student and fellow research projects will have basic and translational components. The students and fellows will be expected to investigate problems that go beyond a single molecule and address questions within the context of cardiovascular disease models. Different portions of these projects will be performed in the laboratories of different investigators, ensuring that students and fellows are exposed to different scientific approaches. All trainees will be involved in activities to enhance their grant and manuscript writing and oral communication skills. Group mentoring by junior and senior faculty will ensure trainees are well qualified to assume positions as leading investigators able to rapidly translate new knowledge into clinical practice. A variety of recruiting strategies will be used to attract a diverse group of trainees that reflect the diversity of our country. The goal is to graduate a diverse group of new Ph.Ds. and post-doctoral fellows that are able to fill a national need for new biomedical scientists to provide the next generation of therapies to reduce the impact of cardiovascular diseases..