Diet, Insulin, Dopamine, and Reward

作为超级风暴桑迪及其后果的结果，两个重大损失使我们的 多PI项目，1 R01 DA033811，饮食，胰岛素，多巴胺，和奖励，PI：玛格丽特·赖斯(联系人)， 肯尼斯·卡尔和马尔滕·里斯。第一个是失去时间，第二个是失去一个转基因小鼠品系， 其中乙酰胆碱(ACh)被基因删除(如Patel等人，NAT中所述)。Commun，2012)。我们 我们要求有成本的延长4个月，并要求补充，以重新建立这个关键的鼠标系列。 我们的实验室功能齐全，目前已获得IACUC的批准，可以进行这方面的所有实验 项目：赖斯协议120313-02,2013年4月9日批准；CARR协议120604-02,2013年2月1日批准；瑞思 120807-01号议定书，2012年8月30日批准。正如我们在最近提交的进度报告中所指出的， 截至2013年5月31日，该项目的未支配余额为总预算的36%(187879美元， 直接+间接为525,864美元)。应该指出的是，30%的结转是必然预期的 因为第一年被截断了30%(至8.5个月。2012年9月15日-2013年5月31日)。小额额外余额(6%) 反映了由于Sandy停机时间导致的供应支出有所减少(尽管工资支持 必须继续)，以及保守的支出，以缓冲未来预算年度的支出 预计将增加，而年度奖励金额将保持不变甚至减少，就像目前发生的那样 预算年度(第二年)。因此，目前的未承付余额对于实现联合国千年发展目标是绝对必要的。 原始申请。目前关于有费用延长和补充的请求是完全不同的 这一问题涉及为恢复桑迪的时间和资源损失而进行的赔偿。

As a consequence of Super-storm Sandy and its aftermath, two significant losses set back progress on our multi-PI project, 1 R01 DA033811, Diet, Insulin, Dopamine, and Reward, PIs: Margaret Rice (contact), Kenneth Carr, and Maarten Reith. The first was lost time, and the second was loss of a transgenic mouse line, in which acetylcholine (ACh) was genetically deleted (as described in Patel et al., Nat. Commun., 2012). We are requesting a with-cost extension of 4 months, and a supplement to re-establish this key mouse line. Our laboratories are all fully functional, and we have current IACUC approval for all experiments in this project: Rice protocol 120313-02, approved 4/9/13; Carr protocol 120604-02, approved 2/1/2013; Reith protocol 120807-01, approved 8/30/2012. As also noted in our recently submitted Progress Report, the unobligated balance on this project was 36% of the total budget as of 5/31/13 ($187,879 of the total award, which was $525,864, direct + indirect). It should be noted that 30% carry-over was necessarily expected because Year 1 was truncated by 30% (to 8.5 mo. 9/15/2012 - 5/31/2013). The small additional balance (6%) reflected some decrease in supply expenditures because of down-time in Sandy (although salary support necessarily continued), as well as conservative spending to buffer future budget years in which expenses are expected to increase, and the annual award amount to remain flat or even decrease, as occurred in the current budget year (Year 2). Thus, the current unobligated balance is absolutely essential to achieve the goals of the original application. The present request for a with-cost extension and supplement is a completely separate issue that addresses compensation to restore losses of time and resources from Sandy.